Fungal secondary metabolism is often considered apart from the essential housekeeping functions of the cell. However, there are clear links between fundamental cellular metabolism and the biochemical pathways leading to secondary metabolite synthesis. Besides utilizing key biochemical precursors shared with the most essential processes of the cell (e.g., amino acids, acetyl CoA, NADPH), enzymes...

BACKGROUND Normal pressure hydrocephalus (NPH) is composed of gait abnormalities, urinary incontinence and decline in mentation. It is uncommonly induced by syphilitic infection. CASE REPORT A 76 year-old male present with gait disturbances, urinary incontinence, declining vision and cognition, with a known diagnosis of NPH. He underwent therapeutic lumbar puncture (LP), which demonstrated le...

To-day few clinicians doubt the efficacy of penicillin as the sole curative agent in the treatment of syphilis, and the wide range of arsenical and bismuth preparations at one time available have virtually disappeared from the pharmaceutical market. The first few sailors to be given penicillin for syphilis were treated by Mahoney, Arnold, and Harris (1943), which event was followed by numerous ...

In continuing the study of the mode of action of penicillin, it was decided to compare the therapeutic effect of single massive doses of crystalline penicillin andof bicillin-1 (benzathine penicillin, which produces therapeutic serum levels for 2 to 4 weeks). Evaluation of the effectiveness of these two preparations was based on clinical observation of the resorption of the chancres, the disapp...

Common signs and symptoms of streptococcal pharyngitis include sore throat, temperature greater than 100.4 degrees F (38 degrees C), tonsillar exudates, and cervical adenopathy. Cough, coryza, and diarrhea are more common with viral pharyngitis. Available diagnostic tests include throat culture and rapid antigen detection testing. Throat culture is considered the diagnostic standard, although t...

A 23-year-old woman from Vanuatu presented to an Australian hospital with a 3-week history of a non-healing ulcer on the lower leg. A swab was submitted for a multiplex polymerase chain reaction designed to investigate genital ulcerative conditions. Haemophilus ducreyi was detected and the gene product was subsequently sequenced, confirming the diagnosis of cutaneous chancroid. The lesion respo...