Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation. Recent studies have shown that the E6 proteins of the cancer associated beta human papillomavirus (HPV) 5 and HPV8 inhibit NOTCH and TGF-β signaling. However,...

CNS: central nervous system IHC: immunohistochemistry MMR: mismatch repair MTS: Muir-Torre syndrome M uir-Torre syndrome (MTS) is an autosomal-dominant variant of Lynch hereditary cancer syndrome. MTS is defined by sebaceous neoplasms occurring in association with 1 or more internal malignancies. The sebaceous neoplasms that characterize MTS are rare among the general population and include seb...

Sebaceous-gland carcinoma can occur alone or as one of the defining features of the Muir-Torre syndrome. Cases occurring below the head and neck are extremely rare. Here we describe the case of a 70-year-old male with Muir-Torre syndrome who had a recurrent sebaceous-gland carcinoma in the left lower extremity that demonstrated (18)F-FDG avidity. An (18)F-FDG-avid lower-extremity sebaceous-glan...

to be associatedwith HPV 16. Higher-weight cytokeratins are encountered in the epidermis as opposed to mucous membranes.2,3 The 2 major differential diagnoses were sebaceous and mucoepidermoid carcinomas.4 Sebaceous carcinomawasexcludedbyoil redOcytoplasmicnegativityand immunohistochemical stains that demonstrated negativity for both adipophilin (except for faint focal positivity in necrotic zo...

To cite: Mestre T, Marques Pinto G. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014204787 DESCRIPTION The human papillomavirus (HPV) can infect the skin and mucous membranes. Common warts, filiform warts, epidermodysplasia verruciformis, mosaic warts and plantar warts represent clinical manifestations of infection with HPV. Giant warts in the hands are very r...

BACKGROUND Recent studies have demonstrated telomerase expression in ophthalmologic sebaceous carcinoma and have suggested possible diagnostic utility in distinguishing these neoplasms from sebaceous adenomas. The aim of this study was to evaluate telomerase expression via human telomerase reverse transcriptase (hTERT) immunohistochemical staining in a spectrum of sebaceous lesions of the skin....

Sebaceous gland carcinoma is a rare fast growing cutaneous cancer. It is derived from the adenxal epithelium of sebaceous glands. Sebaceous carcinomas are generally divided into those occurring in periocular or extraocular locations. Ocular sebaceous carcinomas occur most commonly in upper eye lid, in the elderly with a predilection for females and Asian populations. Due to its clinical resembl...

Correspondence: Stefania Jablonska, MD, or S3awomir Majewski, MD, Department of Dermatology and Venereology, Warsaw School of Medicine, Koszykowa 82a, 02-008 Warsaw, Poland Abstract Epidermodysplasia verruciformis (EV), a rare genetic disease associated with specific human papillomaviruses (HPVs) and skin cancers, regarded as a model of cutaneous viral cancerogenesis, has raised recently an eno...

Epidermodysplasia verruciformis (EV) is a rare inherited syndrome characterized by early onset of numerous plane, vulgaris and versicolor-like warts especially on the face, neck, trunk and extremities with lifelong course and occasional cutaneous squamous cell carcinomas (SCCs) (1,2). Palmar pit-like lesions have been reported in one case of EV from United Arab Emirates (3) and our cases share ...

Although conjunctival squamous cell carcinoma is known to develop as a result of chronic irritation from wearing an ocular prosthesis, orbital sebaceous gland carcinoma arising in an anophthalmic pocket is extremely rare. We report a 68-year-old female who developed a sebaceous gland carcinoma 65 years after her right eye was enucleated (at the age of three years) due to congenital glaucoma. Th...