نتایج جستجو برای: se selectin
تعداد نتایج: 191554 فیلتر نتایج به سال:
L-selectin mediates lymphocyte extravasation into lymphoid tissues through binding to sialomucin-like receptors on the surface of high endothelial venules (HEV). This study examines the biochemical basis and regulation of interactions between L-selectin, an integral transmembrane protein, and the lymphocyte cytoskeleton. Using a detergent-based extraction procedure, constitutive associations be...
BACKGROUND L-selectin mediates leukocyte rolling on endothelium at sites of inflammation, suggesting that L-selectin may be involved in the development of cutaneous lesions of atopic dermatitis (AD). After leukocyte activation, L-selectin is rapidly shed from the cell surface. OBJECTIVE The purpose of this study was to assess leukocyte L-selectin expression and quantitate levels of serum solu...
سابقه و هدف: خطر بیماریهای قلبی عروقی در بیماران همودیالیزی مبتلا سوء تغذیه انرژی - پروتئین بیشتر از بیماران همودیالیزی است که وضعیت تغذیهای مناسبی دارند. عوامل خطر سنتی برای بیماریهای قلبی عروقی مانند BMI و کلسترول تام سرم نمیتوانند توجیه کننده افزایش فراوانی بیماریهای قلبی عروقی در بیماران همودیالیزی مبتلا به سوء تغذیه انرژی - پروتئین باشد. بنابراین، مطالعه حاضر به منظور بررسی رابطه سوء ...
P-selectin is an adhesion molecule expressed on activated platelets and endothelium. It is known to play an important role in atherosclerosis. P-selectin also circulates in plasma in a soluble form (sP-selectin), which induces procoagulant microparticle formation. We investigated the role of platelet versus endothelial P-selectin in generating sP-selectin and in the formation of atherosclerotic...
Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins.
E-, P-, and L-selectin support the adhesion of leukocytes to the vessel wall through the recognition of specific carbohydrate ligands, which often contain sialylated, fucosylated lactosamines such as sialyl Lewis x [sLex; Neu5Ac alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc-]. E-selectin expressed by activated endothelium has been shown to support the adhesion of sLex-bearing colon cancer cells. I...
Introduction PECAM-1 (CD31) (Platelet Endothelial Cell Adhesion Molecule-1) is an adhesive molecule found on the side surfaces of endothelial cells and blood platelets, taking part in the cell adhesion processes. Adhesive molecules are known to play an important part in the inflammatory processes, including inflammations with allergic background. The goal of the study was to assess the sEselect...
In humans and mice, megakaryocytes/platelets and endothelial cells constitutively synthesize P-selectin and mobilize it to the plasma membrane to mediate leukocyte rolling during inflammation. TNF-α, interleukin 1β, and LPS markedly increase P-selectin mRNA in mice but decrease P-selectin mRNA in humans. Transgenic mice bearing the entire human SELP gene recapitulate basal and inducible express...
Selectins play a critical role in initiating leukocyte binding to vascular endothelium. In addition, in vitro experiments have shown that neutrophils use L-selectin to roll on adherent neutrophils, suggesting that they express a nonvascular L-selectin ligand. Using a L-selectin/IgM heavy chain (mu) chimeric protein as an immunocytological probe, we show here that L-selectin can bind to neutroph...
چکید ه سابقه و هدف پلاکت ها نقش مهمی در هموستاز به عهده دارند. از پلاکت متراکم در موارد ترومبوسیتوپنی و اختلال عملکرد پلاکت ها استفاده می شود. از آن جایی که مطالعات پیشین نشان داده اند که فعال شدن پلاکت ها در واحدهای پلاکت متراکم از عملکرد مناسب آن ها می کاهد، در این مطالعه برای ارزیابی فعالیت پلاکت ها در طی تهیه و نگهداری، میزان بیان سطحی p-selectin ، آزمایش تجمع پلاکتی و میزان ph مورد برر...
results the prevalence’s of aa, ac and cc genotypes were 55.2%, 24.1% and 20.7% in cad patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. the frequencies of the c allele were significantly higher in cad patients compared with control groups (p < 0.05). logistic regression analysis revealed a significant association between the c allele and the risk of cad (or = 1.61, 95%c...
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