The role of histamine (HA) as a neurotransmitter in the CNS, although proposed a decade ago (Schwartz, 1975), has been only progressively recognized (reviewed by Schwartz et al., 1980, 1982, 1984; Hough and Green, 1984). One of the key pieces of expenmental evidence has been the demonstration that synthesis of the amine in CNS depends on a specific enzyme, L-histidine decarboxylase (HDC) (Schwa...