Introduction Partial protection against challenge infections with normal cercariae of Schistosoma mansoni or S. japonicum has been induced by immunization with attenuated cercariae of either species. Immunization was successful in a number of different hosts including laboratory rodents and larger mammals. In most cases cercariae or schistosomula were irradiated with gamma or X-irradiation. The...

Previous investigations have shown that in the Lake Region of Sukumaland, Tanganyika, where Schistosoma haematobium is highly endemic, Bulinus (Physopsis) nasutus is responsible for the transmission of that schistosome in small, temporary rain pools. This area is one of low rainfall, and large artificial reservoirs are the chief source of water in the dry season. The role of these reservoirs in...

A single dose of simvastatin and artesunate monotherapy cause damage to the reproductive system schistosomes as well severe tegumental in male worms recovered from mice fed high-fat chow. This study aims investigate whether treatment with multipledose regimes may offer more antischistosomal activity advantages than daily dosing For this purpose, nine weeks post-infection, Swiss Webster were gav...

INTRODUCTION The diagnosis of schistosomiasis mansoni on early stages of infection is important to prevent late morbidity. A simple, cheap, sensitive and specific assay for routine diagnosis of schistosome infection based on the detection of specific IgG for schistosomula tegument antigens (ELISA-SmTeg) was developed by our group. METHODS We describe here an acute outbreak involving a travel ...

Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA) schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to...

The term schistosomiasis encompasses a group of infectious disorders caused by five species of the genus Schistosoma, a blood trematode of outstanding importance in tropical areas. Some of these disorders have long been associated with malignant neoplasia, the most striking association being between disease caused by Schistosoma haematobium, the predominant etiological agent of urinary schistos...

It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after tr...

Profenophos is an organophosphorus pesticide which are used effectively against cotton insects and mites.The present work was carried out to evaluate the molluscicidal activity of pesticides (Profenophos) against Biomphalaria alexandrina snails. Also, the effect of sublethal concentrations of pesticide on the infection of B. alexandrina with Schistosoma mansoni and some enzymes of energy metabo...

INTRODUCTION Schistosomiasis is a chronic disease caused by trematode flatworms of the genus Schistosoma and its control is dependent on a single drug, praziquantel (PZQ), but concerns over PZQ resistance have renewed interest in evaluating the in vitro susceptibility of recent isolates of Schistosoma mansoni to PZQ in comparison with well-established strains in the laboratory. MATERIAL AND M...

Field studies show an association between schistosome infection and atopy, but the effects of anti-helminthic treatment on this association have not yet been investigated in human populations with different schistosome endemicity levels. This study aimed to compare the effects of anti-helminthic treatment on responses directed against the house dust mite Dermatophagoides pteronyssinus (Derp1) a...