Draft genome sequences for Schistosoma japonicum and Schistosoma mansoni are now available. The schistosome genome encodes approximately 13,000 protein encoding genes for which the function of only a small minority is understood. The new genes represent potential intervention targets. Molecular tools are needed to determine the importance of these new genes. There is a role for transgenesis in ...

The overall aims of this project are to assess the safety and immunogenicity of the Schistosoma japonicum vaccine paramyosin among water buffaloes residing in endemic areas. The study was conducted in four villages in Leyte, the Philippines, an area highly endemic for schistosomiasis japonica. One hundred and fifteen (N=115) animals provided baseline stool samples for coprologic examination, wi...