background: a parasitological survey of schistosoma haematobium and s. intercalatum infection among primary schoolchildren in capital area of democratic republic of são tomé and príncipe (drstp) was undertaken. methods: subjects with positive infection were confirmed by the detection of s. haematobium ova in the urine or s. intercalatum ova in the stool by using centrifugation concentration or ...

BACKGROUND Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsi...

Schistosomes have a comparatively large genome, estimated for Schistosoma mansoni to be about 270 megabase pairs (haploid genome). Recent findings have shown that mobile genetic elements constitute significant proportions of the genomes of S. mansoni and S. japonicum. Much less information is available on the genome of the third major human schistosome, S. haematobium. In order to investigate t...

A helminthological study of stool and urine samples from 1037 people from 4 rural communities in Gumau District of Bauchi State, Nigeria, was carried out using formol-ether concentration and direct centrifugation methods respectively. 39.0% of persons examined were infected. Ova of Ascaris lumbricoides, Schistosoma haematobium and S. mansoni were the most common. Trichuris trichiura, hookworm, ...

Anaemia is known to have an impact on child development and mortality and is a severe public health problem in most countries in sub-Saharan Africa. We investigated the consistency between ecological and individual-level approaches to anaemia mapping by building spatial anaemia models for children aged ≤15 years using different modelling approaches. We aimed to (i) quantify the role of malnutri...

An epidemiological study of 1,136 inhabitants from two rural communities in Owan East local government area of Edo State, Nigeria was investigated to ascertain the prevalence, intensities and urinary symptoms in Schistosoma haematobium infections. In both communities, 371 (32.6%) of the villagers screened, excreted S. haematobium with a mean of 40.1 ova per 10 ml of their urine. The pattern of ...

There is renewed interest in natural products as a starting point for discovery of drugs for schistosomiasis. Recent studies have shown that phytol reveals interesting in vivo and in vitro antischistosomal properties against Schistosoma mansoni adult worms. Here, we report the in vitro antischistosomal activity of phytol against Schistosoma haematobium juvenile and adult worms and alterations o...

BACKGROUND The gold standard for the diagnosis of schistosomiasis is the detection of the parasite's characteristic eggs in urine, stool, or rectal and bladder biopsy specimens. Direct detection of eggs is difficult and not always possible in patients with low egg-shedding rates. Confocal laser scanning microscopy (CLSM) permits non-invasive cell imaging in vivo and is an established way of obt...

BACKGROUND Urogenital schistosomiasis due to Schistosoma haematobium is a serious underestimated public health problem affecting 112 million people - particularly in sub-Saharan Africa. Microscopic examination of urine samples to detect parasite eggs still remains as definitive diagnosis. This work was focussed on developing a novel loop-mediated isothermal amplification (LAMP) assay for detect...

BACKGROUND In sub-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia. Anemia results from inflammation, preventing iron recycling and decreasing dietary iron absorption. Hookworm, Plasmodium, and Schistosoma infections contribute to anemia, but their influence on dietary iron absorption and recycling is unknown. OBJECTIVE The objective was to measur...