INTRODUCTION We report the case of a 62-year-old woman diagnosed with sarcomatoid renal cell carcinoma. CASE PRESENTATION A 62-year-old Asian woman presented with macroscopic hematuria. A histological and immunohistochemical study of a tumor biopsy specimen led to a suspected diagnosis of sarcomatoid renal cell carcinoma. She underwent surgical tumor resection that included her left kidney. A...

Objective: To explore the clinical, pathology, and prognosis of sarcomatoid carcinoma of the renal pelvis. Methods: A case of the diagnosis and treatment of sarcomatoid carcinoma of the renal pelvis in our hospital were retrospectively analyzed. Articles were searched from the full-text databases, such as NCBI and PUBMED, the dates of clinical and pathology was collected from the satisfied arti...

OBJECTIVES Recurrence rates for patients with locally advanced renal cell carcinoma (LARCC) remain high. To date the predictors of recurrence in those patients remain controversial. The aim of the present study was to assess the relapse pattern in those patients and identify predictors for recurrence. PATIENTS AND METHODS We evaluated retrospectively 112 consecutive patients who underwent sur...

Malignant pleural mesothelioma (MM) is a rare tumour with high mortality, which can exhibit various morphologies classified as epithelioid, biphasic and sarcomatoid subtypes. To investigate the molecular changes in these tumours, we studied gene expression patterns by combined use of cDNA arrays and tumour tissue microarrays (TMA). Deregulation of the expression of 588 cancer-related genes was ...

BACKGROUND High dose-rate Intra-Operative Radiation Therapy (HD-IORT) is used to provide effective local control for patients with high-risk locally advanced or recurrent tumors. However, the utility of HD-IORT for patients with bladder cancer has not been studied. OBJECTIVE To characterize our institutional experience with HD-IORT in patients with cancer requiring genitourinary surgery, in a...

Nitric oxide regulates cartilage destruction by causing dedifferentiation and apoptosis of chondrocytes. We investigated the role of the mitogen-activated protein kinase subtypes, extracellular signal-regulated protein kinase (ERK)-1/2, and p38 kinase in NO-induced apoptosis of rabbit articular chondrocytes and their involvement in dedifferentiation. Generation of NO with sodium nitroprusside (...

Objective: To verify whether Chinese rice wine polyphenol compounds (RWPC) could inhibit rat aortic vascular smooth muscle cells (VSMCs) dedifferentiation through mammalian target of rapamycin (mTOR)/P70S6K pathway. Methods: The primary culture and identification of rat VSMCs was conducted and VSMCs in passages 3-5 were used for the following experiments. Platelet derived growth factor-BB (PDGF...

PURPOSE Reprogramming of pigmented epithelial cells (PECs) is a decisive process in newt lens regeneration. After lens removal PECs in dorsal iris dedifferentiate and revert to stem cell-like cells, and transdifferentiate into lens cells. Our purpose is to know how global histone modifications are regulated in the reprogramming of PECs. METHODS Iris sections were stained using various histone...

Abstract Background NKX6.1 is a transcription factor for insulin, as well marker ? cell maturity. Abnormal expression in cells, such translocation from the nucleus to cytoplasm or lost expression, has been shown dedifferentiation. Methods We obtained pancreatic sections organ donors and immunofluorescence staining with insulin was performed characterize subjects without type 2 diabetes mellitus...

PURPOSE To examine the ability of retinal pigment epithelial (RPE) cells to modulate Müller cell extracellular matrix contraction through secreted promoters. METHODS Freshly isolated RPE cells were maintained in continuous culture until the morphologic and immunocytochemical changes associated with myofibroblastic dedifferentiation were complete. Secretory products collected from these cells ...