Sarcoidosis is a multisystem disease of unknown origin characterized by the presence of noncaseating epithelioid cell granulomas. When these granulomas develop in the lymph nodes, and the patient does not meet criteria for the diagnosis of systemic sarcoidosis we refer to this as a sarcoid-like reaction. Because of the clinical implications of the diagnosis of lymph node metastasis, mediastinos...

We present an interesting case report of two sarcoid-like lesions on a port-wine stain (PWS) birthmark in a Brazilian patient which on investigation proved to be cutaneous leishmaniasis.

Angiotensin-converting enzyme (ACE) is used as a marker for sarcoid disease activity. We present an observational study of four African-American patients all of whom demonstrated improvement in their sarcoidosis after treatment with ACE inhibitors for hypertension.

Two cases of meningeal sarcoidosis with unusual and misleading presentations are reported. In the first case, CT scan, angiographic, and MRI findings were indistinguishable from those of meningioma. CSF pleiocytosis may help in diagnosing sarcoid pseudo-meningioma. The second patient had transient focal deficits and pachymeningitis of the convexity. The transient deficits were probably of epile...

In patients with malignancy, the common etiologies of granuloma formation are tumor related sarcoid reaction, sarcoidosis, tuberculosis and other granulomatous diseases. Often, the finding of granulomas in malignant patients may obscure the primary malignancy or may mislead towards treatment of infectious and other etiologies. Hence, their proper recognition and necessary follow up is needed to...

As previously reported in this journal, alveolitis may occur in asymptomatic individuals exposed to antigens known as causative agents in hypersensitivity pneumonitis. We found an alveolitis, probably of sarcoid origin, in an apparently healthy volunteer.

Pulmonary involvement is common in sarcoidosis, an immunemediated inflammatory disorder that is characterized by noncaseating granulomas in tissue. Sarcoid patients with advanced pulmonary disease, especially end-stage pulmonary fibrosis, risk developing pulmonary hypertension (World Health Organization group III pulmonary hypertension secondary to hypoxic lung disease). Increased levels of end...