A survey of the literature shows that the experience with radiotherapy (RT) in the local treatment of osteosarcoma (OS) is limited. This is due to various reasons: OS is a rare tumor and surgery is the treatment of choice with high local control rate, and uncertainty exists in regard to the efficacy and tolerance of radiotherapy. Publications on this topic were analyzed and will be reviewed. Fu...

The influence of gas-phase oxygen on the growth of Au nanoparticles on Mo-doped CaO films has been investigated by means of low temperature scanning tunnelling microscopy and X-ray photoelectron spectroscopy. Whereas at ideal vacuum conditions, only 2D Au islands develop on the oxide surface, the fraction of 3D deposits increases with increasing O2 pressure until they become the dominant specie...

Experiments were conducted to study the acidogenesis of a dairy wastewater in batch reactors at pH 5.5 and 55°C. There was a biased fermentation sequence for carbohydrate and protein, and the protein fermentation was delayed by carbohydrate. The production of hydrogen was exclusively from the fermentation of carbohydrate. Acetate and butyrate concentrations both increased rapidly at the beginni...

1 Arak Üniversitesi Tıp Fakültesi, Moleküler Tıp Araştırma Merkezi, Arak, İran 2 Epidemiyoloji ve Mikrobiyoloji Araştırma Enstitüsü, Minsk, Beyaz Rusya, 3 Beyaz Rusya Pulmonoloji ve Fitizyoloji Araştırma Enstitüsü, Minsk, Beyaz Rusya, 4 Shahid Beheshti Üniversitesi Tıp Fakültesi, Masih Daneshvari Hastanesi, Mikobakteriyoloji Araştırma Merkezi (MAM), Tahran, İran 5 Shahed Üniversitesi Tıp Fakült...

By the synergistic catalysis of samarium ion and mercaptan, a series of 5-oxoalkanals was converted to (substituted) delta-lactones in efficient and stereoselective manners. This one-pot procedure comprises a sequence of acetalization, Tishchenko reaction and lactonization. The deliberative use of mercaptan, by comparison with alcohol, is advantageous to facilitate the catalytic cycle. The reac...

We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its transesterification in the presence of ethanol with special emphasis on the risks of drug-drug interaction. The hydrolysis of CDP323 was evaluated in vitro using human liver and intestinal microsomes and recombinant human carboxylesterases (hCES1 and 2) and was shown to ...

This study characterized the kinetics, variability, and factors that affect UDP–glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the highand low-affinity components differed by more than an order of magnitude (13 6 6 vs. 374 6 175 mM), but were comparable in terms of the maximal...

Numerous plant species are considered weeds in agronomic cropping systems. Weeds have many attributes undesirable to crop producers, not the least being the ability to reduce crop yields through competition for resources such as sunlight, water, nutrients, and space. Weeds also may harbor insects and provide a host for certain plant pathogens. Some weed species, such as wild garlic and eastern ...