Residues Tyr59, Gly78, Ser79, Met103, Gln107, Ile136 and Glu137 in human arsenic (+3 oxidation state) methyltransferase (hAS3MT) were deduced to form a potential hydrogen bond network around S-adenosylmethionine (SAM) from the sequence alignment between Cyanidioschyzon merolae arsenite S-adenosylmethyltransferase (CmArsM) and hAS3MT. Herein, seven mutants Y59A, G78A, S79A, M103A, Q107A, I136A a...

We introduce a computer program which calculates an agent’s optimal behavior according to Casebased Decision Theory (Gilboa and Schmeidler 1995) and use it to test CBDT against a benchmark set of problems from the psychological literature on human classification learning (Shepard, Hovland, and Jenkins 1961). This allows us to evaluate the efficacy of CBDT as an account of human decision-making ...

In a classic psychological science experiment, Shepard and Metzler (1971) discovered that the time participants took to judge whether two rotated abstract block figures were identical increased monotonically with the figures' relative angular disparity. They posited that participants rotate mental images to achieve a match and that mental rotation recruits motor processes. This interpretation h...

Shoot apical meristem (SAM) domes derived from five different outdoor and in vitro sources of juvenile and mature Eucalyptus urophylla x Eucalyptus grandis akin genotypes were compared. Overall measurements of SAM dome height H and diameter D ranged from 2 to 35 μm and 20 to 80 μm, notwithstanding significant differences according to the various physiological origins of plant material investiga...

Systolic anterior motion (SAM) of the mitral valve (MV) can be a life-threatening condition. The SAM can result in severe left ventricular outflow tract obstruction and/or mitral regurgitation and is associated with an up to 20% risk of sudden death (which is substantially lower in hypertrophic cardiomyopathy (HCM)). The mechanisms of SAM are complex and depend on the functional status of the v...

In the process of morphogenesis primordia of lateral organs, like leaves or flowers, are formed at the shoot apical meristem (SAM). In order to maintain the ability to organ formation, the SAM itself has to be self-perpetuated, i.e. its general shape and size have to be maintained, despite the fact that portions of SAM periphery are continuously used up for lateral organ formation. Thus growth ...

ing a H-atom from substrate. These and other kinetics studies demonstrated that PFL-AE could undergo multiple turnover events, with the 150 PFL activations per PFL-AE reported in Table 1 not the upper limit, but rather a number limited by the PFL:PFL-AE ratio in the steady-state kinetics assays. As can be seen from the data summarized in Table 1, PFL-AE is one of the few radical SAM enzymes dem...

SMSr/SAMD8 is an ER-resident ceramide phosphoethanolamine synthase with a critical role in controlling ER ceramides and suppressing ceramide-induced apoptosis in cultured cells. SMSr-mediated ceramide homeostasis relies on the enzyme's catalytic activity as well as on its N-terminal sterile α-motif or SAM domain. Here we report that SMSr-SAM is structurally and functionally related to the SAM d...

Understanding how electrons travel through organic matter is important in designing materials for organic microelectronics[1] and understanding biological electron-transport processes.[2, 3] Herein we describe a simple experimental procedure to measure rates of electron transport across organic thin films having a range of structures, compare the data for several types of films, and outline a t...

A method to solve stochastic partial differential equations on random domains consists in using a one to one random mapping function which transforms the random domain into a deterministic domain. With this method, the randomness is then supported by the constitutive relationship of the material. In this paper, this method is applied in electrokinetics in the case of scalar potential and vector...