The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland cells of multiple P2 receptor subtypes. Curren...

BACKGROUND Protein-tyrosine sulfation is a post-translational modification of an unknown number of secreted and membrane proteins mediated by two known Golgi tyrosylprotein sulfotransferases (TPST-1 and TPST-2). We reported that Tpst2-/- mice have mild-moderate primary hypothyroidism, whereas Tpst1-/- mice are euthyroid. While using magnetic resonance imaging (MRI) to look at the thyroid gland ...

OBJECTIVE To delineate the spectrum of salivary gland tumors in our setup. SETTING The Aga Khan University Medical Centre, Karachi. METHOD Tumors were analysed considering histological type, age and sex of the patients and anatomic location. The diagnosis of individual tumours was based on the 1991 World Health Organisation Classification. RESULTS During the span of eight years (1991-1998...

Oncocytic lipoadenoma is a rare salivary gland tumour composed of adipose tissue and oncocytic epithelial cells in varied proportions. This tumour is still not included in the current WHO classification of salivary gland neoplasms. We herein report a further case of oncocytic lipoadenoma originating in the parotid gland of a 55-year-old woman. The tumour presented as a slowly growing asymptomat...

Estrogen receptors (ERs) expression has been studied in salivary gland tumors, however, there are conflicting results regarding its expression in the literatures. The aim of this study was to investigate the expression of estrogen receptors protein (ERs) in pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) of salivary glands using immunohistochemistry. 35 cases of intraoral minor sali...

Salivary glands are important for secretion of saliva, which is essential for bolus formation, swallowing and maintaining a healthy oral cavity [1]. Salivary glands consist of acinar and duct cells. Injury to salivary glands, such as the damage that occurs following radiation treatment for head and neck cancer, causes a decrease in the number of acinar cells and the ability of the glands to pro...

Chronic sclerosing sialadenitis (CSS) (Kuttner's tumor) is a benign fibroinflammatory condition most commonly affecting the submandibular gland. It presents as hard mass that mimics salivary gland neoplasms. We report an unusual presentation of Kuttner's tumor parotid in order to raise awareness this rare and underreported entity.

BACKGROUND AND PURPOSE Although radiation induced damage to the salivary gland is a known complication of radioactive iodine ((131)I) therapy for thyroid carcinoma, prediction of the severity and reversibility of sialoadenitis is difficult. Our aim was to correlate the extent of salivary dysfunction assessed by salivary gland scintigraphy with changes in the volume and attenuation of salivary g...

Over the past few decades, salivary gland tumor pathology has evolved. This includes recognition of newly defined entities as well as reclassification of other salivary gland tumors [1]. The development of genetic tests have shown that some salivary gland tumors have genetic abnormalities which are specific to a histologic type such as MECT1– MAML2 gene fusion in mucoepidermoid carcinoma and PL...