Objectives. The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver (ACLF) are inseparable from the role systemic inflammatory response. S100A8 S100A9 associated with excessive cytokine storm play a decisive part within process inflammation. We aimed to clarify them in predicting prognosis hepatitis B virus-related ACLF (HBV-ACLF). Methods. levels were analyzed...

Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins, S100A8 and S100A9. It multifunctional protein expressed mainly neutrophils released extracellularly activated or damaged cells mediating broad range of physiological pathological responses. has been more than 20 years since the implication S100A8/A9 in inflammatory process was shown; however, evaluation ...

The family of calgranulins includes S100A8 (calgranulin A), S100A9 B), which can appear as a heterodimer known S100A8/A9 or calprotectin, and S100A12 C). These proteins are related to different inflammatory conditions, immune-mediated diseases, sepsis considered biomarkers potential interest. This study aims evaluate if A12 could change in pigs with diarrhea due E. coli compare the changes othe...

Ureaplasma parvum, an opportunistic pathogen of the human urogenital tract, has been implicated in contributing to chorioamnionitis, fetal morbidity, and fetal mortality. It has been proposed that the host genetic background is a critical factor in adverse pregnancy outcome as sequela to U. parvum intra-amniotic infection. To test this hypothesis we assessed the impact of intrauterine U. parvum...

Despite several new therapeutic options, multiple myeloma (MM) patients experience relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead the development of novel treatment strategies. The S100 family is comprised 21 calcium binding protein members with 17 genes located in 1q21 region, which commonly amplified MM. Dysregulated expression associ...

Doxorubicin (DOX)-induced cardiotoxicity limits its broad use as a chemotherapy agent. The development of effective and non-invasive strategies to prevent DOX-associated adverse cardiac events is urgently needed. We aimed examine whether how low-intensity pulsed ultrasound (LIPUS) plays protective role in DOX-induced cardiotoxicity. Male C57BL/6J mice were used establish models both acute chron...