We examined changes of event-related potentials (ERPs) while participants learned stimulus-to-stimulus relations in an S1-S2 task. The design allowed for separating processes of associative learning from nonspecific effects. Participants had to respond to S2 by a left or right key-press dependent on S2 identity (letter W or M). Preparation for S2 could be improved by using the associative infor...

Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions offering a range of important therapeutic applications. To evaluate a system for large-scale production of this peptide in the mammary glands of transgenic livestock, we generated transgenic rabbits carrying fusion genes in which a synthetic DNA coding for human IGF-I (hIGF-I) was placed...

It is known that ternary complexes of myosin subfragment 1 (S1) with ADP and the Pi analogs beryllium fluoride (BeFx) and aluminum fluoride (AlF4-) are stable analogs of the myosin ATPase intermediates M* x ATP and M** x ADP x Pi, respectively. Using kinetic approaches, we compared the rate of formation of the complexes S1 x ADP x BeFx and S1 x ADP x AlF4- in the absence and in the presence of ...

BACKGROUND The somatosensory temporal discrimination threshold (STDT) measures the ability to perceive two stimuli as being sequential. Precisely how the single cerebral structures contribute in controlling the STDT is partially known and no information is available about whether STDT can be modulated by plasticity-inducing protocols. METHODOLOGY/PRINCIPAL FINDINGS To investigate how the cort...

†Background Environmental factors greatly impact plant gene expression and concentrations of cellular metabolites such as sugars and amino acids. The changed metabolite concentrations affect the expression of many genes both transcriptionally and post-transcriptionally. †Recent Progress Sucrose acts as a signalling molecule in the control of translation of the S1 class basic leucine zipper tran...

We show that if F :S1 → S1 is a homeomorphism of the unit circle S1 and the rotation number α(F ) of F is irrational, then the Schröder equation Φ ( F(z) = e2πiα(F Φ(z), z ∈ S1, has a unique (up to a multiplicative constant) continuous at a point of the limit set of F solution. We apply this result to prove that if F is a non-trivial continuous and disjoint iteration group or semigroup on S1 an...

S1 Table. Properties of available TCR structures. For each X-ray structure TCR names used in the literature are listed and the relevant TCR chains within one biological unit are indicated. Loci and alleles of the TRAV, TRBV, TRAJ, and TRBJ were assigned using the IMGT Gene/DB [1] and the sequences of the CDR loops are listed for comparison of the different subtypes (Mutations within the framewo...