Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5'-cyclo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine (cdG). Herein, the result of replication of a plasmid containing S-cdA in Escherichia coli is reported. S-cdA was found mutagenic and highly genotoxic. Viability and mutagenicity of the S-cdA construct were dependent on functional pol V, bu...

Background and Purpose The aim of the study was to correlate the severity of poststroke pathological crying with lesion size and location. Methods Twelve selected stroke patients were ranked in terms of overall clinical severity of the syndrome of pathological crying, and the size and location of the stroke lesion(s) were determined by magnetic resonance imaging. Results The patients with the c...

Perlman, M., and Reisner, S. H. (1973). Archives of Disease in Childhood, 48, 627. Asymmetric crying facies and congenital anomalies. The frequency of hypoplasia of the depressor anguli oris muscle in a newborn population was 41 in 6360 (1 in 155). No adverse factors were noted in the obstetric background of affected infants and the pathogenesis of the lesion is not clear. The incidence of asso...

Females 8,) ,ial Grouping (I ) ParticularlI thlrifty andic iiid(uistriolis paren'ts (2) Ordinaiy workingI-class " parents (3) Very poor parenits . lReferred bV ScXhool MILO. Ini-patients (ITH. ) H. Aver. No. of weeks in Howp. Family History of Rhc. Tnfection History of Acuite Rheuimatisimi LUss acuite pains in liml)s Tonsillitis .. . Tonsils remove( .. Transient apical systolic murmtur. Mitral ...

We report on a case of focal haematopoietic hyperplasia occurring in the haematopoietic marrow in a lumbar vertebral body, of a young man. The PET scan performed showed high uptake of the radiotracer in the vertebral body of L3 and a MRI of the lumbar spine confirmed the vertebral lesion. A biopsy of the L3 vertebral body lesion was performed and the histological result was of chronic myeloprol...

This review explores evidence for the reversibility of atherosclerosis and augmentation of angiography with noninvasive arterial wall imaging. Meta-analysis from coronary angiographic trials demonstrates that regression and stabilization are 1.5 to 2 times more common in treated than placebo subjects, and progression is reduced by half in treated subjects. Odds ratios for clinical coronary even...

BACKGROUND The aim of this study was to determine the relationship between the morphological and physiological information of coronary CT angiography (CCTA) and stress myocardial perfusion imaging (S-MPI) from the standpoint of risk stratification of patients with intermediate to high probability of coronary artery disease (CAD). METHODS AND RESULTS In total, 51 patients underwent both CCTA a...