نتایج جستجو برای: s disease pd
تعداد نتایج: 2167246 فیلتر نتایج به سال:
Abstract Introduction: It is demonstrated that the degree of clinical improvement in Parkinson's disease (PD) achieved by deep brain stimulation (DBS) is largely dependent on the accuracy of lead placement. In addition, individual variability in the situation of subthalamic nucleus (STN) is responsible for spatial inter-individual fluctuations of the real patient's target. Objecti...
The palladium(II) dimer, [Pd(C,N-C(6)H(4)CH(2)NMe(2))Cl](2) reacts with two equivalents of the NHC·CS(2) zwitterionic ligands [NHC = IPr (1,3-diisopropylimidazol-2-ylidene), ICy (1,3-dicyclohexylimidazol-2-ylidene), IMes (1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene), IDip (1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), SIMes (1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene)] in the ...
Peroxiredoxins (Prx), a family of peroxidases that reduce intracellular peroxides with the thioredoxin system as the electron donor, are highly expressed in various cellular compartments. Among the antioxidant Prx enzymes, Prx2 is the most abundant in mammalian neurons, making it a prime candidate to defend against oxidative stress. Here we report that Prx2 is S-nitrosylated (forming SNO-Prx2) ...
The bromocyclopentadienyl complex [(eta5-C5H4Br)Re(CO)3] is converted to racemic [(eta5-C5H4Br)Re(NO)(PPh3)(CH2PPh2)] (1 b) similarly to a published sequence for cyclopentadienyl analogues. Treatment of enantiopure (S)-[(eta5-C5H5)Re(NO)(PPh3)(CH3)] with nBuLi and I2 gives (S)-[(eta5-C5H4I)Re(NO)(PPh3)(CH3)] ((S)-6 c; 84 %), which is converted (Ph3C+ PF6 -, PPh2H, tBuOK) to (S)-[(eta5-C5H4I)Re(...
Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, patient-derived stem cell model of PD allowing comparison of A53T α-synuclein (α-syn) mutant cells ...
OBJECTIVE To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA). BACKGROUND RRIV assessment is a simple procedure, reflecting mainly vagal efferent activity. Reduced RRIV was reported in MSA. METHODS RRIV at rest and after 120 s of deep breathing was assessed blindly to clinic...
Reaction of the potassium salt of N-thiophosphorylated thiourea 2-PyNHC(S)NHP(S)(OiPr)(2) (HL) with PdCl(2) in aqueous MeOH leads to the formation of two mononuclear homoleptic complexes [Pd{2-PyNHC(S)NP(S)(OiPr)(2)-1,5-S,S'}(2)] ([Pd(L-1,5-S,S')(2)]) and [Pd{2-PyNHC(S)NP(S)(OiPr)(2)-1,5,7-N,N',S}(2)] ([Pd(L-1,5,7-N,N',S)(2)]), while the mechanically induced solid-state reaction of KL and PdCl(...
Parkinson disease (PD) is a chronic, progressive and debilitating disease. This study aimed to determine the relationship between the dimensions of Roy Adaptation Model (RAM) and General Health (GH) and Satisfaction with Life (SWL) in PD patients. This was a cross-sectional study. Samples were selected from the PD patients in 2016. The data was gathered by demographic, RAM, GH and SWL Scale que...
objective(s): parkinson's disease (pd) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. evidence indicates that pd occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. it is reported that soy genistein, an estrogen agonist phytoestrogen, display neuro...
Although oxidative stress has been strongly implicated in the pathogenesis of Alzheimer disease (AD) and Parkinson disease (PD), the identities of specific protein targets of oxidative damage remain largely unknown. Here, we report that Cu,Zn-superoxide dismutase (SOD1), a key antioxidant enzyme whose mutations have been linked to autosomal dominant neurodegenerative disorder familial amyotroph...
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