Gallic acid (GA), rutin(R), quercitin (Q), ellagic acid (EA) and sitosterol(S) isolated from the methanolic extract of the leaves of Tectona grandis were formulated as 0.2 % ointment in emulsifying base and were evaluated for their wound healing activity. The animals were divided into eight groups of six animals each. Groups 1 used as control, group 2 used as a standard i.e. nitrofurazone ointm...

There is a need for innovation in plant-derived pharmaceuticals, food supplements and nutraceutical products regarding the use of more eco-sustainable solvents for their extraction. Furthermore, the poor oral bioavailability of several phytochemicals with health promoting effects stimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents (NADES) are form...

Sevoflurane and propofol are widely used in pediatric anesthesia. Neurotoxicity of sevoflurane and propofol in developing brain has been reported and these effects raise concerns on the usage of the drugs. We investigated the influence of rutin, a flavonoid on the neurodegenerative effects of sevoflurane and propofol and on memory and cognition in neonatal rodent model. Separate groups of neona...

Boerhaavia erecta L. (Nyctaginaceae) is a medicinal weed, indigenous to tropical America, but presently pantropical and appear to constitute a functional leafy vegetable of certain communities. The taxon is reported to possess antiparasitic, antifungal, antibacterial, antiviral, antihistaminic, antioxidant and hepatoprotective properties. The residue of the ethanolic leaf-extract was fractionat...

Objective: Several phytochemical agents have been known to exhibit a neuroprotective effect. Among them, curcumin, linalool, rutin, safranal, and thymoquinonewere widely investigated and neuroprotective activity of each of them was shown by several studies. This work was planned to investigate whether different combinations of them could induce better neuroprotective effect against glucose/seru...

BACKGROUND Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive, and effective treatment does not exist....