This paper proposes a new method for RTK post-processing. Different from the traditional forward-backward Kalman filter, in our method, whole system equation is built on graphical state space model and solved by factor graph optimization. The position solution provided forward filter used as linearization points of model. Constant variables, such double-difference ambiguity, will exist constant...

Receptor tyrosine kinases (RTKs) and Notch (N) proteins are different types of transmembrane receptors that transduce extracellular signals and control cell fate. Here we examine cell fate specification in the Drosophila retina and ask how N acts together with the RTKs Sevenless (Sev) and the EGF receptor (DER) to specify the R7 photoreceptor. The retina is composed of many hundred ommatidia, e...

A previous study demonstrated that proximal tubule cells regulate HCO(3)(-) reabsorption by sensing acute changes in basolateral CO(2) concentration, suggesting that there is some sort of CO(2) sensor at or near the basolateral membrane (Zhou Y, Zhao J, Bouyer P, and Boron WF Proc Natl Acad Sci USA 102: 3875-3880, 2005). Here, we hypothesized that an early element in the CO(2) signal-transducti...

The majority of growth factor receptors are composed of extracellular, transmembrane, and cytoplasmic tyrosine kinase (TK) domains. Receptor tyrosine kinase (RTK) activation regulates many key processes including cell growth and survival. However, dysregulation of RTK has been found in a wide range of cancers, and it has been shown to correlate with the development and progression of numerous c...

The Medium Scale Travelling Ionospheric Disturbances (MSTIDs) are the most frequent wave signatures in the ionosphere, with amplitudes up to several TECUs, periods from several hundreds to one-two thousands of seconds, and propagation velocities from 50 to +300 m/s, mainly equator-eastward in winter/fall seasons, and westward in summer/spring seasons (M. Hernandez-Pajares et al., Radio Science,...