Objective Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Mate...

osteoporosis is a metabolic bone disease affecting mostly elderly women. as metabolizing enzymes, the roles of few cytochromes have been studied in osteoporosis development. the aim of this study was to assess for the first time the association of cyp2e1 and cyp1a1 polymorphisms and osteoporosis in postmenopausal women. 112 postmenopausal women presenting osteoporosis and 93 age and sex matched...

background : to determine the frequency of the single nucleotide polymorphism m287t in exon 9 of the as3mt gene in iranian population and to assess the difference in allele frequencies with other ethnicities. subjects and methods : genotyping analysis was performed on 150 healthy subjects using the pcr-rflp assay. we used chi-square analysis to check the deviation from hardy–weinberg equilibriu...

background: acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. leptin (lep) and leptin receptor (lepr) gene polymorphisms can increase cardiovascular risks. the aim of this study was to investigate association between the frequencies of lep and lepr gene polymorphisms and subclinical atherosclerosis in acromegalic patients. methods: forty-four ac...

obesity is currently considered as a serious global health problem which is influenced by environmental and genetic factors. association of genetic variants with obesity is widely scrutinized in recent years. the aim of this study was to evaluate present data on genetics of obesity in iranian population in a systematic review study. to obtain all related studies, google scholar, pubmed, and per...

tap1 and tap2 genes encode heterodimeric molecule involved in endogenous antigen processing. the present study was undertaken to find out the possible association between tap1 and tap2 polymorphisms and risk of pulmonary tuberculosis (ptb) in a sample of iranian population. polymorphisms of tap1 (rs1057141, rs1135216) and tap2 (rs2228396, rs241447, rs67511411, rs141555015) were determined in 17...

macrophages and t-lymphocytes are involved in immune response to mycobacterium tuberculosis. macrophage produces interleukin (il)-1 as an inflammatory mediator. il-1 receptor antagonist (il1-ra) is a natural antagonist of il-1 receptors. in this study we aimed to examine the possible association between the variable number of tandem repeats (vntr) of the il-1 receptor antagonist (il1rn) gene an...