Rhabdomyosarcoma (RMS), a neoplasm characterized by undifferentiated myoblasts, is the most common soft tissue tumour in children. Therapeutic resistance is common in RMS and is often caused by acquired defects in the cellular apoptotic program. Smac mimetic compounds (SMCs) are a novel class of inhibitor of apoptosis (IAP) antagonists that are currently under clinical development as cancer the...

In the last decade, there has been a lot of focus on sustainable development in the electrical power industry to meet the growing energy demand. This has led to an increase in the integration of renewable energy sources (RES). In addition to being abundantly available, the RES offers advantages such as low environmental impact and increased social development of rural communities which are impe...

Rheumatic mitral valve stenosis (RMS) is a complication of rheumatic heart disease (RHD) and leads to significant morbidity and mortality. RHD is a chronic inflammatory and autoimmune disease that is associated with cytokine activities. The etiology of RMS is not fully understood yet. Interleukin (IL)-17 and IL-23 have a key role in development of the autoimmunity. The expression of these cytok...

Mice with heterozygous loss of the tumor suppressor Patched1 (Ptch) develop rhabdomyosarcoma (RMS)-like tumors. However, Ptch transcripts are consistently overexpressed in these tumors. We have recently shown that the upregulated transcripts are derived from the mutated Ptch allele thus leading to the hypothesis that the wild-type allele is repressed during RMS development. Here we describe epi...

Rights Management Services (RMS) are used to enforce access control in a distributed environment, and to cryptographically protect companies’ assets by restricting access rights, for example, to view-only, edit, print, etc., on a per-document basis. One of the most prominent RMS implementations is Microsoft RMS. It can be found in Active Directory (AD) and Azure. Previous research concentrated ...

Standard models of promotion tournaments assume that …rms can commit to arbitrary tournament prizes. In this paper, a …rm’s ability to adjust tournament prizes is constrained by the outside labor market, through the wages other …rms are willing to o¤er to the promoted and unpromoted workers. The paper shows that su¢ ciently patient …rms may be able to retain some control over the tournament pri...

Large artefacts which compromise EEG data quality are generated when electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are carried out concurrently. The gradient artefact produced by the time-varying magnetic field gradients is the largest of these artefacts. Although average artefact correction (AAS) and related techniques can remove the majority of this artefact, t...

A variety of reference models such as CMMI, CobiT or ITIL support IT organizations to improve their processes. Although these reference models (RM) cover different domains they also share some similarities. There are organizations that address multiple domains and want to use different RMs. As RMs may overlap in some processes, we present an approach to compare RMs’ procedures which is based on...

Current mitigation levels for noise transients impinging on marine mammals are specified by rms pressures. The rms measure critically relies upon choosing the size of averaging window for the squared pressures. Derivation of this window is not standardized, which can lead to 2-12 dB differences in rms sound pressure for the same wave forms. rms pressure does not represent the energy of the nois...