The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for risperidone after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis, and thermal stress conditions. The liquid chromatographic separation was achieved isocratically on a symmetry C18 column (5 μm size, 250 mm × 4.6 mm i.d.) using a mobile phase containing methan...

BACKGROUND Antipsychotic medications are the mainstay for schizophrenia treatment, and olanzapine and risperidone are popular choices among atypical antipsychotics in Norway. Our aim was to develop a decision analytic model to evaluate the cost-effectiveness of antipsychotics in a Norwegian setting. METHODS The Positive and Negative Symptom Scale (PANSS) score was used to measure effectivenes...

Corresponding author: Narges Beyraghi, MD Associated Professor of Psychiatry, Shahid Beheshti University of medical science, Taleghani Hospital, Tehran, Iran. Tel:22277026 Email: [email protected] Objective: Sexual dysfunction in patients who take antipsychotics causes a decline in their quality of life and medication acceptance. Considering the restrictions in cross sectional design of many ...

Priapism can be associated with sickle cell anemia, perineal trauma, leukemia, and other neoplasms (1,2). It can also be associated with the use of systemic or intracorporeal vasoactive agents and antidepressants, antipsychotics, antihypertensives, and recreational drugs (4). Although typical antipsychotics are thought to be related to priapism, there are some case reports on the relationship b...

The mechanism of action of a relatively new antipsychotic drug-Risperidone differs from conventional antipsychotics like Haloperidol. We compared low dosages of Risperidone with near equivalent dosages of Haloperidol in first episode drug naive Acute and Transient Psychotic disorder. A single blind randomised four-week study protocol was employed. Highly significant and comparable efficacy as a...

This article will review the case of a young patient with mental retardation, autistic disorder, and Tourette Syndrome who exhibited a favourable treatment response preferentially to risperidone. His presentation, however, was complicated by an exquisite sensitivity to risperidone displayed in the form of recurrent oculogyric crises. In this article, we will outline a review of the case, a surv...

BACKGROUND Several clinical studies have established the efficacy, safety, and tolerability of long-acting risperidone administered once every 2 weeks in patients with schizophrenia or schizoaffective disorder. This report evaluates preliminary efficacy, safety, tolerability, and pharmacokinetic data for a novel (once-monthly) administration of long-acting injectable risperidone 50 mg in patien...

Background: Aripiprazole is a D2 receptor (D2R) partial agonist with a favourable clinical profile, compared with other antipsychotics. Previous in vivo studies indicated that acute and short-term administration with aripiprazole affected the GSK3β (glycogen synthase kinase 3β)-dependent pathways, NMDA receptor and CREB (cAMP-responsive element-binding protein 1), which may contribute to its th...

The study objectives were to examine the effects of the atypical antipsychotic drugs olanzapine, risperidone, and quetiapine on core temperature in the rat in relation to such effects produced by clozapine and to compare possible in vivo intrinsic efficacy of olanzapine, risperidone, and quetiapine at dopamine (DA) D(1) receptors with such effects previously shown for clozapine. Core temperatur...

OBJECTIVE Most controlled studies comparing second-generation and conventional antipsychotics have focused on the acute treatment of schizophrenia. The authors compared symptom outcomes, side effects, and social adjustment in stable schizophrenia outpatients who received 2 years of maintenance treatment with risperidone or haloperidol. METHOD This was a 2-year, randomized, double-blind compar...