Rhomboid domain containing 1 (RHBDD1), is a member of the rhomboid protease family, which has a pivotal role in the progression of numerous severe malignancies. However, its role in colorectal carcinoma (CRC) remains to be elucidated. In the present study, RHBDD1 was shown to be widely expressed in CRC cell lines. Lentivirus-mediated RNA interference was employed to knockdown RHBDD1 expression ...

closure of donor site of the flap has special problems. reduction of this site will decrease the morbidity of operation. in this study, we present our experience in donor site size reduction. methods between 2006 and 2008, 15 patients with skin and soft tissue defects underwent operation. in all patients, coverage of defect was performed with various flaps. substratum horizontal mat-tress sutur...

introduction: malignant tumors of the parotid gland account scarcely for 5% of all head and neck tumors. most of these neoplasms have a high tendency for recurrence, local infiltration, perineural extension, and metastasis. although uncommon, these malignant tumors require complex surgical treatment sometimes involving a total parotidectomy including a complete facial nerve resection. severe fu...

reconstruction of breast with transverse rectus abdominis myocutaneous (tram) flap is the standard for reconstruction of breast following mastectomy. in this article, authors report their experience with pedicled tram flap reconstruction of the breast. records for the patients who had undergone breast reconstruction with pedicled tram flap were retrieved. records of outpatient follow-ups were a...

We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not show any myeloma cells. Histologic examination of the tumor revealed aggregation...

In Drosophila imaginal wing discs, the achaete-scute (ac-sc) proneural genes and rhomboid (veinlet) are expressed in highly resolved patterns that prefigure the positions of sensory organs and wing veins, respectively. It is thought that these patterns are generated by a combination of factors (a prepattern) regulating these genes. We provide evidence for the existence of this prepattern by ide...