FK866 is a specific inhibitor of NAMPT and induces apoptosis of leukemic cells by depletion of intracellular NAD(+). Since up-regulation of NAMPT is associated with several cases of cancers, including leukemias, we asked whether in leukemic cells inhibition of NAMPT involves p53 pathway. We observed that FK866 induced apoptosis and reduced cell proliferation in NB-4, OCI-AML3 and MOLM-13 cell l...

Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine B lymphomas CH31, CH12.Lx, BKS-2, and WEHI-231 and the human B lymphomas BJAB, RAMOS, RAJI, OCI-Ly7, and OCI-Ly10 was strongly inhibited by SP600...

Objective: Diffuse large B cell lymphoma (DLBCL) incidence rates have increased year by year, a part of them poor clinical outcomes, but the underlying mechanism involved is still unclear. Chemokines been thought to play an important role in occurrence and development tumors, they are poorly studied DLBCL. CC-Chemokine Ligand 2 (CCL2), most representative CC chemokine family members, through bi...

The objective of this paper is to perform an uncertainty and sensitivity analysis of the predictions of the Benchmark Simulation Model (BSM) No. 1, when comparing four activated sludge control strategies. The Monte Carlo simulation technique is used to evaluate the uncertainty in the BSM1 predictions, considering the ASM1 bio-kinetic parameters and influent fractions as input uncertainties whil...

BACKGROUND Tuberculum sellae meningiomas (TSMs) present a special symptom because of the adherence and compression to the optic nerve, optic artery, and the chiasm. A significant number of patients with TSMs appear visual deficits. This study aimed to investigate the surgical indications of exploring the optic canal and visual prognostic factors in the neurosurgical treatment of TSMs. METHODS...

The bromodomain and extra terminal (BET) family protein bromodomain containing protein 4 (BRD4) is an epigenetic regulator recently identified as a therapeutic target for several hematological cancers, notably mixed lineage leukemia-fusion acute myeloid leukemia (MLL-AML). Here, we show that the BRD4 bromodomain inhibitor JQ1 is highly active against the p53-wild-type Ontario Cancer Institute (...

PIK3CA has been extensively investigated from its molecular mechanism perspective and epidemiological association with its mutations in different types of cancers. However, little has been reported regarding the clinicopathological significance of PIK3CA expression in diffuse large B cell lymphoma (DLBCL). In the present study, we investigated the clinicopathological significance of PIK3CA in D...

background chronic kidney disease (ckd) is a common medical condition among children and obsessive-compulsive disorder (ocd) is a frequent, chronic, costly, and disabling disorder among them. objectives the aim of this study was to investigate obsessive-compulsive disorder (ocd) in children with early stages of ckd, and to compare it with the occurrence of ocd in healthy children. patients and ...

Članak polazi od činjenice da svaka civilizacija i kultura svjedoče o smislu vrijednosti životinja u svagdanjem čovjekovu životu osmišljavanju njegove egzistencije. Autor uzima obzir samo nekoliko životinja, njih osam, neke parovima, a pojedinačno, to one koje hodaju po zemlji. Svaka stoji naslovu rada s istaknutim karakteristikama čini jedno poglavlje. Životinje su uzete razmatranje na temelju...

this study evaluated 2 elt textbooks (four corners, book 2 and four cornersbook 3) drawing on bloom’s revised taxonomy (brt); it examined the extent towhich these elt textbooks could demonstrate the 6 cognitive categories of the brt(i.e., remembering, understanding, applying, analyzing, evaluating, and creating) intheir activities. to this end, content analysis was done to obtain the frequency ...