Anti-HIV combination therapies in a single formulation currently target only HIV-1 reverse transcriptase via two different mechanisms of action by associating a nucleoside and a non-nucleoside reverse transcriptase inhibitor. These combination therapies are therefore referred to as multi-class combination products. The elvitegravir Quad pill (Gilead Sciences), when approved by the Food and Drug...

Highly active antiretroviral therapy (HAART) consists of a combination of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance. Despite being the first antivirals described to be effective against HIV, reverse transcriptase inhibitors remain the cornerstone of HAART. There are two broad classes of reverse transcriptase inhibitor, the n...

OBJECTIVE Our aim is to use multi-dimensional Bayesian network classifiers in order to predict the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and protease inhibitors given an input set of respective resistance mutations that an HIV patient carries. MATERIALS AND METHODS Multi-dimensional Bayesian network classifiers (MBCs) are probabilistic graphical models especially d...

Discrimination between the amplification of mRNA and contaminating genomic DNA is a common problem when performing a reverse transcriptase-polymerase chain reaction (RT-PCR). Even after treatment of the samples with DNAse, it is possible that negative controls (samples in which no reverse transcriptase was added) will give positive results. This indicates that there was amplification of DNA, wh...

Purpose of the study The first antiretroviral therapy was introduced in Vietnam in 1990 and included two nucleoside reverse transcriptase inhibitors (NRTIs). More recently, nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) were available, particularly through different programmes. In this context, it is interesting to survey the HIV drug resistance and also t...

Submit Manuscript | http://medcraveonline.com Abbreviations: ART: Antiretroviral Therapy; NNRTI: NonNucleoside Reverse Transcriptase Inhibitor; NRTI: Nucleoside/N Ucleotide Reverse Transcriptase Inhibitor; PI: Protease Inhibitor; AZT: Zidovudine; D4T: Stavudine; DDI: Didanosine; TDF: Tenofovir Disoproxil Fumarate; EFV: Efavirenz; NVP: Nevirapine; ETR: Etravirine; LPV/R: Lopinavir and Ritonavir;...