The objective was to develop an elemene oil/water (o/w) microemulsion and evaluate its characteristics and oral relative bioavailability in rats. Elemene was used as the oil phase and drug, polysorbate 80 as a surfactant along with ethanol, propylene glycol, and glycerol as the cosurfactants. The microemulsion was prepared by mixing method, or ultrasonication method in an ultrasonic bath. Its t...

in this paper the dynamic of a droplet on a surface with a hole is investigated under gravitational effect by using lattice boltzmann method. incompressible two-phase flow with high density ratio proposed by lee is considered. cahn’s theory is used to observe the wettability of the surface in contact with liquid and gas phases. several parameters such as contact angle, surface tension and gravi...

Use of microemulsion in enhanced oil recovery has become more attractive in recent years because of its high level of extraction efficiency. Experimental investigations have been made on characterization of microemulsions of oil-brinesurfactant/cosurfactant system for its use in enhanced oil recovery (EOR). Sodium dodecyl sulfate, propan-1-ol and heptane were selected as surfactant, cosurfactan...

The aim of this study is to develop a microemulsion product from a plant essential oil having the highest anti-tyrosinase activity. The in vitro anti-tyrosinase activity of six essential oils extracted from six edible plants was compared. The oil of Cymbopogon citratus demonstrated the highest activity which was significantly nontoxic to normal human cells. The GC-MS data indicated that gerania...

The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methanol solution, isotretinoin undergoes complete photodegradation just within a few minutes of light e...

The three-component ionic microemulsion system consisting of AOT/water/decane shows an interesting phase behavior in the vicinity of room temperature. The phase diagram in the temperature-volume fraction (of the dispersed phase) plane exhibits a lower consolute critical point around 10% volume fraction and a percolation line, cutting across the plane starting from the vicinity of the critical p...

We examined the phase behavior of various polyoxyethylene sorbitan fatty acid ester (polysorbates)/ethanol/isopropyl myristate (IPM)/150 mM NaCl solution (NaClaq) systems in order to prepare a microemulsion containing a low ratio of ethanol, which is more suitable for in vivo application. Using polyoxyethylene sorbitan trioleate (Tween 85), which has a large lipophilic moiety, as a surfactant c...

he photon correlation spectroscopy and small-angle X-ray scattering is used for study the mixture of C12E5 microemulsion with PEG in order to determine structure and dynamic of the system. Photon correlation spectroscopy experiment showed an exponential relaxation for pure C12E5 microemulsion that come from Brownian motion of oil nano-droplets in water. The shape of the relaxation changed with ...

The purpose of this review is to give an insight into the considerable potential of lecithin based nanocarriers. The lecithin microemulsion and closely related microemulsion based systems are currently of interest to pharmaceutical researchers. Conventional systems for topical delivery of drugs meet many hindrances like reduced permeation and entrapment efficiency. Lecithin nanocarriers with th...