PURPOSE The pig eye is similar to the human eye in terms of anatomy, vasculature, and photoreceptor distribution, and therefore provides an attractive animal model for research into retinal disease. The purpose of this study was to characterize retinal histology in the developing and mature pig retina using antibodies to well established retinal cell markers commonly used in rodents. METHODS ...

Using high performance liquid chromatography, the level of retinoids was determined in the bovine pineal gland, retina, retinal pigment epithelium, cortical and subcortical brain tissues, skeletal muscle and the liver. Except the retina, the bovine pineal gland possesses levels of retinol and retinyl esters significantly higher than other brain tissues and muscle. However, unlike the retina, th...

ARTICLES DISCUSSED: Ma, Y., Li., T. Monitoring dynamic growth of retinal vessels in oxygen-induced retinopathy mouse model. Journal Visualized Experiments. (170), e62410 (2021). Guan, Xie, B. Zhong, X. Retinal organoid induction system for derivation 3D tissues from human pluripotent stem cells. e62435 Rose, K., Lokappa, S. Chen, J. Two peeling methods the isolation photoreceptor cell compartme...

Retinal degeneration, characterised by the progressive death of retinal neurons, is most common cause visual impairment. Oxysterols are cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate homeostasis in retina. Preclinical and clinical studies have suggested a connection between oxysterols degeneration. Here, we summarise early recent work related to retin...

Diabetic retinopathy (DR) is a retinal disease representing one of the main causes vision loss in developed countries. In early stage DR, disruption blood barrier (BRB) observed, and it will lead to vascular permeability visual impairment. Therefore, protection against breakdown BRB may be useful strategy for prevention DR. Matrix metalloproteinases (MMPs) plays an important role degradation ex...

An early step in the formation of the optic pathway is the directed extension of retinal ganglion cell (RGC) axons into the optic fiber layer (OFL) of the retina in which they project toward the optic disc. Using analysis of knock-out mice and in vitro assays, we found that, in the mammalian retina, Slit1 and Slit2, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal ...

Abstract The computations performed by a neural circuit depend on how it integrates its input signals into an output of own. In the retina, ganglion cells integrate visual information over time, space, and chromatic channels. Unlike former two, integration is largely unexplored. Analogous to classical studies spatial integration, we here study in mouse retina identifying stimuli for which activ...

The retina of anamniotes (fish and amphibia), unlike the CNS of most vertebrates, can regenerate neurons following injury. Using the highly ordered mosaic of single and double cones in the retina of the adult green sunfish (Lepomis cyanellus) as our model system, we examined the events that followed the surgical excision of a small patch of central retina. After surgery there was a transient el...