The action potential duration (APD) of ventricular myocytes depends on the length of the preceding diastolic interval (DI) in a relationship termed “electrical restitution.” The APD shortens with decreasing cycle length and thus with decreasing DI.1 The teleological advantage of this phenomenon is that it provides increased time for excitation-contraction coupling at long cycle lengths while pr...

Quantitative modeling y gy, ABSTRACT Background: Marked changes in ventricular APD restitution and associated alternans

OBJECTIVE Abnormal autonomic nerve activity is a strong prognostic marker for ventricular arrhythmias but the mechanisms underlying the autonomic modulation of ventricular fibrillation (VF) initiation are poorly understood. We examined the effects of direct sympathetic (SS) and vagus (VS) nerve stimulation on electrical restitution, alternans and VF threshold (VFT) in a novel isolated rabbit he...

Abstract The law on the availability of restitution in context illegal contracts is unclear. Several irreconcilable approaches have been proposed at common search a solution to question whether or not party an contract who has benefitted from any right restitution. This article examines Ghanaian judicial approach and ascertains extent which it sheds light this difficult issue. It does so by exa...

Abstract The most widely used model for granular gases is perhaps the inelastic hard-sphere (IHSM), where grains are assumed to be perfectly smooth spheres colliding with a constant coefficient of normal restitution. A much more tractable Maxwell (IMM), in which velocity-dependent collision rate replaced by an effective mean-field constant. This simplification has been taken advantage many rese...

Restitution is a monetary remedy paid by perpetrator or third party to victim their family. It can be implemented returning property, payment for losses suffering, reimbursement of costs. However, restitution not applicable all types crimes; thus, victims have access it.The issue legal protection still an ongoing discourse, and many parties believe that its implementation far from perfect in ne...

The oblique collisions between two axisymmetric disks moving on a flat horizontal surface are described in terms of impact modeling based the assumption that normal and tangential restitution mechanisms operate independently friction. Describing these usual Coulomb formulation, model allows for an interpretation some “anomalous” experimental data reported literature. These data, corresponding t...

Cardiac restitution has been described both in terms of ionic models-systems of ODE's-and in terms of mapping models. While the former provide a more fundamental description, the latter are more flexible in trying to fit experimental data. Recently we proposed a two-dimensional mapping that accurately reproduces restitution behavior of a paced cardiac patch, including rate dependence and accomm...

Glucose was infused intravenously into cats prior to cerebral ischemia. Brain concentrations of glucose, measured in 7 regions, were elevated 2.5-fold compared to those of non-infused animals. Ischemia of 15 or 30 minutes duration caused a greater accumulation of lactic acid in the brain of glucose-infused animals. Post-ischemic restitution of cerebral ATP, phosphocreatine, and lactate during 9...