Being able to stop (or inhibit) an action rapidly as in a stop-signal task (SST) is an essential human ability. Previous studies showed that when a pre-stimulus cue warned of the possible need to stop a response in an upcoming trial, participants' response time (RT) increased if the subsequent trial required a "go" response (i.e., "go" RT cost) relative to a trial where this uncertainty was not...

conclusions this study showed that the developed rrt-pcr assays are rapid, reliable, reproducible, specific, sensitive, and simple tools for detection of mers-cov. finally, a kit consisting of two assay signatures and controls was assembled, which can be distributed to public health laboratories in iran to support international mers-cov surveillance and public health response. results the upe a...

In vitro amplification assays, such as real-time quaking-induced conversion (RT-QuIC) are used to detect aggregation activity of misfolded prion protein (PrP) in brain, cerebrospinal fluid (CSF) and urine samples from patients with a prion disease. We believe that the method also has a much broader application spectrum. In the present study, we applied RT-QuIC as a pre-screening test for substa...

HIV-1 reverse transcriptase (RT) is an important target for drugs used in the treatment of AIDS. Drugs known as non-nucleoside RT inhibitors (NNRTI) appear to alter the structural and dynamical properties of RT which in turn inhibit RT's ability to transcribe. Molecular dynamics (MD), principal component analysis (PCA), and binding free energy simulations are employed to explore the dynamics of...

Twelve patients with Parkinson's disease (PD) and 12 age-matched controls completed a visual reaction time (RT) task to assess the effect of temporal parameters on response preparation. Simple and choice RT conditions were presented in separate blocks. In both conditions, preparatory intervals of various durations (1, 3 and 5 s) were introduced between an auditory warning signal and the visual ...

Most models assume that response time (RT) comprises the time required for successive processing stages, but they disagree about whether information is transmitted continuously or discretely between stages. We tested these alternative hypotheses by measuring when movement-related activity began in the frontal eye field (FEF) of macaque monkeys performing visual search. Previous work showed that...

Hypofractionated radiotherapy (RT) has been employed to treat hepatocellular carcinoma (HCC). The present study aimed to report the treatment effects, the dose-response associations and the factors that are associated with radiation-induced liver disease (RILD) in a high-dose hypofractionated RT procedure. A total of 40 patients with non-metastatic HCC who underwent RT for local control of irra...