tannase has several important applications in food, feed, chemical and pharmaceutical industries. in the present study, production of tannase by mutant strain, penicillium sp. ez-zh390, was optimized in submerged fermentation utilizing two statistical approaches. at first step, a one factor at a time design was employed to screen the preferable nutriments (carbon and nitrogen sources of the med...

incorporation of functional foods and nutraceuticals such as carotenoids which suffer from poor water solubility and low bioavailability into nano-sized delivery systems can improve their solubility, stability and oral bioavailability. the aim of this study was to prepare β-carotene nanodispersion and investigate the effects of preparation parameters by means of response surface methodology usi...

conclusions we found ccd and rsm very effective in optimizing hib culture conditions, and hib biomass production was greatly influenced by ph and incubation temperature. therefore, optimization of the growth factors to maximize hib production can lead to 1) an increase in bacterial biomass and prp productions, 2) lower vaccine prices, 3) vaccination of more susceptible populations, and 4) lower...

The present work is an attempt to model, analyze, and control the flow at the base of an abruptly expanded circular duct by using design of experiments (DOE) and response surface methodology (RSM). Tiny-jets in the form of orifice were positioned at an interval of 900, 6.5 mm from the primary axis of the main jet of the nozzle. Experiments were conducted to measure two responses namely, base pr...

background: hepatitis b infection is a major public health problem worldwide. dental students who are frequently in contact with body fluids like blood and saliva are still at high risk for hbv exposure. the aim of this study was to evaluate the effectiveness of hbv vaccine and personal factors associated with serologic evidence of the immune response. methods: a descriptive-cross sectional stu...