Contact hypersensitivity (CHS) mouse model induced by 2, 4-dinitrofluorobenzene (DNFB) is thought to be a T helper 1 (Th1)-dominant response and used for investigating anti-inflammatory and immunosuppressive agents. However, it is hardly used for screening large-scale drugs because of the large number of animals and complex mechanisms involved in-vivo. In this study, we focused on whether T lym...

The goal of the present report is to compare several published methods of analyzing drug-drug interaction data. The compared methods are the curve-shift analysis, isobologram, combination index, and universal surface response analysis, and the comparison was based on analysis of published cytotoxicity data of combinations of two anti-folate agents. Major findings are as follows. The curve shift...

abstract   background: irregular working hours, including night work and shift work, have been found to be associated with alteration in various levels of biochemical factors. and some studies have showed association between shift work and blood biochemical disturbances in blood. in this epidemiological study we investigated, whether regular schedule of working hours can minimize the associated...

BACKGROUND Although shift work is necessary in many health-care settings, research suggests that it can have detrimental effects on performance in health-care providers. AIMS To determine if a change in decision-making occurred across a 12-h day shift in a sample of registered nurses. METHODS The participants were nurses working a 12-h day shift (7 a.m.-7 p.m.) at a large hospital in the so...

Structural properties, energies behavior and NBO analysis was performed for1-5 prototrophic shift endinelboran where substitutions like H, CH3 and CF3 that were placed on Benzene were investigated by usingDFT-B3LYP/6-311+G** level of theory. The Results show that, -BH2 shift doesn’t take place and a kind of[1,3] shift for borotrophic occured. In prototrophic shift, however, [1,5] transition eas...

BACKGROUND Shift work is indicated to be associated with adverse metabolic disorders. However, potential effects of shift work on metabolic syndrome (MetS) and its components have not been well established. METHODS In total, 26,382 workers from Dongfeng-Tongji Cohort were included in this study. Information on shift work history was gathered through questionnaires and metabolic traits were me...

conclusions the study findings highlight the importance of the mental aspect of fatigue in this working group. these results have possible implications for workers’ health and well-being and for the design of shift work systems, for industrial workers. background shift work is a well-recognized occupational health hazard in both industrialized and industrially developing countries. prolonged wo...

background: occupational asthma (oa) is the most common occupational lung disease in developed countries. one of the causative agents is metal fume that may be encountered in steel industries. screening for the oa is mainly performed by questionnaire but in our country spirometry is used more commonly. objective: to compare the diagnostic value of the venables standardized respiratory questionn...