Metabolomic research has revealed that metabolites play an important role in prostate cancer development and progression. Previous studies have suggested that prostate cancer cell proliferation is induced by advanced glycation end products (AGEs) exposure, but the mechanism of this induction remains unknown. This study investigated the molecular mechanisms underlying the proliferative response ...

We are investigating the role of the early response transcription factor, nerve growth factor inducible A gene (NGFI-A), as a modulator of retinoblastoma (RB) gene transcription in prostate cells. Examination of the RB promoter reveals a novel element GCGGGGGAG located at nucleotides 152-144 upstream of the methionine initiation codon. This sequence shares strong homology with the consensus NGF...

Research has consistently shown that males play violent video games more frequently than females, but factors underlying this gender gap have not been examined to date. The present approach examines the assumption that males play violent video games more, because they anticipate more enjoyment and less guilt from engaging in virtual violence than females. This may be because males are less empa...

Spatial information mediation extends principles of information mediation to processing of spatial queries against multiple heterogeneous spatial databases and spatial processing nodes. This architecture is based on (1) a set of spatial wrappers which expose capabilities of spatial data sources and services in a homogeneous way, (2) spatial mediation software responsible for query planning and ...

This paper describes a formalism for context mediation based on Feature Logic. The formalism enables a distinction to be drawn between integrity and translational aspects of mediation. It is independent of the relational model, though easily used within it. The formalism makes precise the concept of 'context' and provides a framework for mediation between disparate data sources.

Information integration has a long history since humans started using and collecting information. But, it been strong focus of IT research many recent years. It deals with providing unified transparent access to collection heterogeneous data sources. In information integration, the formulization global schema is difficult task that manages multiple, autonomous This paper presents semantic syste...

The Equal Employment Opportunity Commission (EEOC) has experienced dramatic backlogs of pending charges over the years. In 1977, the backlog reached an all-time high of 130,000 cases pending. Recently, the EEOC announced that the backlog had been reduced to 29,890 cases. A significant portion of this reduction is attributab le to an increased use of mediation. During FY 2001, 7,800 of the 94,59...

leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. leptin and itsreceptor (ob-r) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. the goal of this study was determination of the presence of leptin receptor mrna in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...

This paper explores pragmatic socialization by examining episodes of two to three - year-old children’s crying and adults’ responses this in preschools: Sweden Japan. Based on approximately 100 hours naturally occurring interactions, it focuses that emerged within peer conflict, analyzes ways teachers structured a triadic framework mediation. The results show how mediated using (1) question-res...