Thoughtful House Center for Children 3001 Bee Cave Rd. Austin, TX 78746 Phone: +1 512 732 8400 A.W.–Director, M.B.–Advisory Board, A.R.–Dir. of Operations, D.H.–Dir. of Technology, J.J.–Executive Board Member, C.S.–Cantab Corresponding Author, Email: [email protected] Emeritus Professor of Chemistry, University of Kentucky Executive Director, Defeat Autism Now! Chairman, Coalition for ...

Previous studies indicate that the motor areas of both hemispheres are active when observing actions. Here we explored how the motor areas of each hemisphere respond to the sounds associated with actions. We used transcranial magnetic stimulation (TMS) to measure motor corticospinal excitability of hand muscles while listening to sounds. Sounds associated with bimanual actions produced greater ...

Sensory axons become functional late in development when Schwann cells (SC) stop proliferating and differentiate into distinct phenotypes. We report that impulse activity in premyelinated axons can inhibit proliferation and differentiation of SCs. This neuron-glial signaling is mediated by adenosine triphosphate acting through P2 receptors on SCs and intracellular signaling pathways involving C...

Response inhibition is disturbed in several disorders sharing impulse control deficits as a core symptom. Since response inhibition is a cognitively and neurally multifaceted function which has been shown to rely on differing neural subprocesses and neurotransmitter systems, further differentiation to define neurophysiological endophenotypes is essential. Response inhibition may involve at leas...

This chapter highlights the importance of the problem of action coding, that is, the cognitive representation of action, for theories of S-R compatibility. An action-concept model of S-R compatibility is presented, based on considerations of Lotze and HarleB on the emergence of voluntary action. It assumes that the cognitive code of any perceivable, movement-contingent event--hence, action effe...

The relationship between the dose of intravenously administered streptozotocin (a N-nitroso derivative of glucosamine) and the diabetogenic response has been explored by use of the following indices of diabetogenic action: serum glucose, urine volume, and glycosuria, ketonuria, serum immunoreactive insulin (IRI), and pancreatic IRI content. Diabetogenic activity could be demonstrated between th...

Immunoglobulin M (IgM) is the largest antibody molecule and is deposited in the glomeruli in a wide variety of both primary and secondary glomerulopathies. The data on its pathogenic role are conflicting till date. A recent study provides evidence for the involvement of natural antibody IgM in fixing and activating complement and causing glomerular injury, proteinuria, and glomerulosclerosis in...

Theories assuming an effect-based coding of action predict that motor responses become activated by the perception of the responses' sensory effects. In accordance with this prediction it was found that responding to a visual target is faster and more accurate when the target is briefly preceded by the visual effect of the required response. Most importantly, this effect-induced response primin...

This paper is about the design and implementation of a wiki-based knowledge management system for improving emergency response. Most organizations face difficult challenges in managing knowledge for emergency response, but it is crucial for response effectiveness that such challenges be overcome. Organizational members must share the knowledge needed to plan for emergencies. They also must be a...