نتایج جستجو برای: replicative capacity
تعداد نتایج: 283292 فیلتر نتایج به سال:
Certain "protective" major histocompatibility complex class I (MHC-I) alleles, such as B*57 and B*27, are associated with long-term control of HIV-1 in vivo mediated by the CD8+ cytotoxic-T-lymphocyte (CTL) response. However, the mechanism of such superior protection is not fully understood. Here we combined high-throughput fitness profiling of mutations in HIV-1 Gag, in silico prediction of MH...
Genomic fidelity in the humans is continuously challenged by genotoxic reactive oxygen species (ROS) generated both endogenously during metabolic processes, and by exogenous agents. Mispairing of most ROS-induced oxidized base lesions during DNA replication induces mutations. Although bulky base adducts induced by ultraviolet light and other environmental mutagens block replicative DNA polymera...
As human epithelial cells age in culture, protein levels of the tumor suppressor protein p16 continue to increase resulting in growth arrest independent of telomere length. Telomere-independent senescence induced by the p16/Rb tumor suppressor pathway prevents many epithelial cells from becoming immortalized by telomerase alone. Differences in culture conditions have been hypothesized to modula...
The correlation between telomerase activity, telomere lengths, and cellular replicative capacity has led to the theory that maintenance of telomere lengths by telomerase acts as a molecular clock to control replicative capacity and senescence. Regulation of this molecular clock may have applications in the treatment of cell aging and tumorigenesis, although little is presently known about the r...
Antigen-specific multifunctional T cells that secrete interferon-γ, interleukin-2 and tumour necrosis factor-α simultaneously after activation are important for the control of many infections. It is unclear if these CD8(+) T cells are at an early or late stage of differentiation and whether telomere erosion restricts their replicative capacity. We developed a multi-parameter flow cytometric met...
Abstract Bacterial transposons propagate through either non-replicative (cut-and-paste) or replicative (copy-and-paste) pathways, depending on how the mobile element is excised from its donor source. In well-characterized E. coli transposon Tn 7 , a heteromeric TnsA-TnsB transposase directs cut-and-paste transposition by cleaving both strands at each end during excision step. Whether similar pa...
مقدمه: یکی از شایعترین اختلالات ریوی در بزرگسالان بیماری های انسدادی مزمن ریه (copd) است که شامل برونشیت مزمن و آمفیزم می باشد. شدت این اختلال در تعیین میزان پاسخ به درمان موثر است و لذا امروزه سعی می شود معیارهای مختلفی در جهت درجه بندی شدت بیماری copd استفاده شود که از جمله آنها می توان به معیارهای بالینی ارائه شده توسط american thoracic society (ats) اشاره نمود. شناسایی ارتباطات موجود بین ای...
Dermal fibroblasts produce a collagen-rich extracellular matrix, which confers mechanical strength and resiliency to human skin. During aging, collagen production is reduced and collagen fragmentation is increased, which is initiated by matrix metalloproteinase-1 (MMP-1). This aberrant collagen homeostasis results in net collagen deficiency, which impairs the structural integrity and function o...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید