نتایج جستجو برای: renin activity
تعداد نتایج: 1146990 فیلتر نتایج به سال:
The interrelationship between renal hemodynamics and the renin-angiotensinaldosterone system in 28 nonazotemic cirrhotic patients has been studied. Patients were divided into three groups: A) Patients without ascites nor edema; B) Patients with ascites and a relatively high sodium excretion (41.9 ± 12.9 mmol/day); and C) Patients with ascites and very low sodium excretion (4.8 ± 0.6 mmol/day). ...
Renin is the rate-limiting enzyme of the reninangiotensin system (RAS). In addition to its enzymatic activity to generate angiotensin I, renin also signals through the (pro)renin receptor to exert angiotensin II-independent effects. In this study we examined the effect of renin inhibition on the development of diabetic nephropathy. Male DBA/2J mice were induced to diabetes with streptozotocin, ...
An unusual case of orbital tumor with high renin content and severe hypertension is described. The patient was a 15-year-old girl with juvenile hypertension (200-140 mmHg) associated with right exophthalmos and hypokalemia. The patient showed extremely high levels of plasma renin activity and plasma aldosterone concentration. No difference was present in plasma renin activity from either side o...
1. Complete ligation of the aorta between the origins of the two renal arteries in the rat produces a predictable form of accelerated hypertension. Changes in the blood pressure, plasma renin activity and renal histological lesions have been studied. 2. Group 1 rats and their control group (group 2) received tap water, and group 3 and its control group (group 4) received sodium chloride solutio...
Ethacrynic acid, a potent inhibitor of sodium reabsorption in the ascending limb of Henle's loop, produces a sharp rise in renal venous renin activity within 5 min after intravenous administration in anesthetized dogs. This response persists when volume depletion is prevented by returning urinary outflow to the femoral vein. Comparable studies with chlorothiazide, a diuretic with little or no e...
An age-dependent study of plasma renin activity (PRA), kidney renin activity (KRA), and plasma renin substrate was carried out in rats with spontaneous hypertension during the prehypertensive, the early hypertensive, and the established hypertensive phases of their disease. PRA and KRA were both significantly elevated before and during the initial phase of hypertension and normal or subnormal d...
In mature outbred Swiss male mice, submandibular gland renin enzyme activity is 4- and 10-fold higher than in glands of prepubescent males and mature females, respectively. Levels of translatable renin mRNA have been studied in mouse submandibular gland during postnatal development and following administration of testosterone. The [35S]methionine-labeled cell-free translation products directed ...
BACKGROUND There are breed differences in several blood variables in healthy dogs. OBJECTIVE Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. ANIMALS Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). METHODS Prospective observational study. Circulating concentrati...
1. Plasma volume, 24 h urine sodium and total body potassium were similar among 89 previously untreated patients with mild hypertension and 89 control subjects matched for age and sex. 2. Total body potassium correlated with renin activity in both hypertensive patients and controls. 3. Renin activity and total body potassium fell significantly with age in both groups. 4. The relationship betwee...
GANTEN, DETLEV, ANA MARQUIZ-JULIO, PIERRE GRANGER, KARL HAYDUK, KLAUS PETER KARSWNKY,ROGER BOUCWER, AND JACQUES GENEST. Renz'n ilz dog brain. Am. J. Physiol. 221(6): 17331737. 1971 .-Brain tissue of dogs contains high renin activity. After peritoneal dialysis in nephrectomized dogs for up to 12 days, levels of renin activity remain as high as in control dogs. Kenin substrate and angiotensin are...
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