Attempts to minimize ischemic injury by interrupting a given ischemic period might be compromised if repeated bouts of reperfusion injury occurred. To determine whether intermittent ischemia improved or worsened functional and morphologic outcome of renal ischemia, halothane-anesthetized rats underwent a right nephrectomy and placement of a snare about the left renal vascular pedicle at 37 degr...

BACKGROUND Renal ischemia-reperfusion injury is a common cause of acute kidney injury in intensive care and surgery. Recently, novel organic mononitrites of 1,2-propanediol (PDNO) were synthesized and shown to rapidly and controllably deploy nitric oxide in the circulation when administered intravenously. We hypothesized that intravenous infusion of PDNO during renal ischemia reperfusion would ...

Hyperglycaemia is most probably a contributing factor in the development of ischaemic acute renal failure (ARF) in many patients. Both clinical and experimental data suggest that hyperglycaemia increases the risk of ARF. Present study was designed to evaluate in Glimepiride reduced on experimentally induced ischemia/reperfusion in diabetic rats. Type 2 Diabetes was induced in rats by a single i...

Ischemia/reperfusion (I/R) injury is one of the main causes acute kidney injury. The pathological mechanisms underlying renal I/R are complex and remain uncertain. protective effects antioxidant properties geraniol against ischemia reperfusion damage were investigated in our study. 28 Wistar albino male rats randomly selected 4 groups n = 7 created. A right nephrectomy surgery was conducted to ...

  Background: Simvastatin is a widely used medication in cardiac care. Here we evaluate the role of ATP sensitive potassium (KATP) channels in simvastatin induced renal protection after renal ischemia/reperfusion (I/R) injury.    Methods: A total of 81 male Wistar rats, were treated with simvastatin (10 and 20mg/kg/day gavage, one week). Some groups received glibenclami...

BACKGROUND Ischemic preconditioning, a phenomenon induced by brief ischemia and reperfusion periods, renders an organ tolerant to subsequent prolonged ischemia. This study evaluated different schedules of preconditioning the kidney to assess the role of nitric oxide (NO) and determine the effects of preconditioning on kidney transplantation. METHODS In study design A, to determine the optimum...

Abstract Introduction Intestinal ischemia-reperfusion is still a relevant clinical problem, especially in newborns and the elderly. In this piece of work, we check utility curcumin dexmedetomidine to overcome damage induced by reperfusion, both locally distant organs, using α-tocopherol as comparison. Methods female Wag/RijHsd rats, superior mesenteric artery was clamped for 1 h; then, animals ...

Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients. Mechanisms underlying reperfusion-associated injury include recruitment and activation of leukocytes and release of inflammatory mediators. In this study, we investigated the renal effects of acute administration of AVE0991, an agonist of Mas, the angiotensin-(1-7) receptor, the angiotensin-...

BACKGROUND AND AIMS Renal ischemia followed by reperfusion causes remote liver injury. This research was planned to investigate whether 3-aminobenzamide (3-AB), has any preventive effect against distant liver injury triggered by renal IR. MATERIALS AND METHODS Twenty four rats were randomly divided into three different groups Each group has 8 rats. The groups were as follows: (1) Sham operate...

We examined the renoprotective effects of l-carnosine (beta-alanyl-l-histidine) on ischemia/reperfusion (I/R)-induced acute renal failure (ARF) in rats. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. In vehicle (0.9% saline)-treated rats, renal sympathetic nerve activity (RSNA) was significantl...