The paper proposes modeling calcein release kinetics (considered hydrophilic drug model) from interpenetrating network matrix of hydrogel type, based on combinations of two polymers, of which the chitosan is common. The release process is analyzed for different increasing time intervals, divided upon release kinetics evolution. For each time interval, a dominant release mechanism was identified...

The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on dru...