The ability of two thermodynamic approaches to predict the solubility of solid compounds in hot pressurized water is studied and compared. The Regular Solution Theory, based on the solubility parameter concept, and UNIFACbased models were applied to calculate the solute activity coefficient and then, solubility predictions were compared with experimental data reported in the literature. The ana...

This work was investigated the protein solubility properties of meat from chicken in different body part. The effects of fresh and freezing condition were studied on the protein solubility as a functional property of slaughter and non slaughtering chicken meat. Solubility of proteins was significantly reduced for slaughtering fresh meat and in contrast, non slaughtering fresh meat shows the hig...

A new extension of the Hildebrand solubility approach which describes drug solubility in solvent mixtures showing multiple solubility peaks, the chameleonic effect, is proposed. The experimental solubilities of oxolinic acid were measured at 25 degrees C in solvent mixtures of ethanol-water and ethanol-ethyl acetate. A plot of the mole fraction of the drug against the solubility parameter (delt...

clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (adp) to its platelet receptor and the subsequent adp-mediated activation of the glycoprotein gpiib/iiia complex, thereby inhibiting platelet aggregation. oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. the aim of this investigation was ...

      This study presents the influence of hydroxypropyl-β-cyclodextrin (HPBCD) on the aqueous solubility of acyl esters of cyproterone. First, a number of esters of cyproterone were synthesized. Then the phase solubility analysis of the compounds in the presence of HPBCD was investigated in phosphate buffer solution at a pH of 7.4. To gain a better understanding of the complexation mechanism, ...

We report measurements of the solubility hydrogen in pure water and sodium chloride brine molality 2.5 mol/kg at temperatures between 323.15 K 423.15 pressures up to about 40 MPa. The estimated expanded relative uncertainty given temperature pressure is 3%, with a coverage factor 2. new results, together data from literature for brine, are used construct simple model predict brines as function ...

The solubility of K2SO4 in water at 25°C was determined. Comparing the value ofthermodynamic solubility product constant, Ksp(th), (Ksp(th) = exp (-ΔGodiss RT) of the mentionedsalt to the value of concentration solubility product, Ksp(c) which is obtained from the observedsolubility, s/moL-1, Ksp(c) = 4s3, revealed a great difference. The difference can be satisfactorilyexplained using Debye- H...

The Hildebrand's solubility parameters have been calculated for 18 ionic liquids from the inverse gas chromatography measurements of the activity coefficients at infinite dilution. Retention data were used for the calculation. The solubility parameters are helpful for the prediction of the solubility in the binary solvent mixtures. From the solubility parameters, the standard enthalpies of vapo...

Background and objectives: Essential oils are used for their flavors and fragrances and their medicinal properties in food, cosmetic, agriculture and pharmaceutical industries. This study was focused on the selection of the best solvent(s) which would increase water solubility of ketone and phenol classes of essential oils. Methods: The solubility of s...

It is well established that amyloid fibril solubility is protein specific, but how solubility depends on the interactions between the fibril building blocks is not clear. Here we use a simple protein model and perform Monte Carlo simulations to directly measure the solubility of amyloid fibrils as a function of the interaction between the fibril building blocks. Our simulations confirms that th...