In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...

A method of relative location for explosions using Rayleigh waves is developed and tested. It involves cross correlating a wavetrain with a previously recorded signal from the same source region and &?.t&mining a relative "travel-time" from the peak in the -ross correlation trace. Locations are fairly accurate, but do not compare with the precision obtained with body waves and relative travel-t...

the objective of the study was to develop a simple, specific and stability-indicating hplc method for the simultaneous determination of creatine phosphate sodium (cps) and its related substances in pharmaceutical formulation. separation of creatine phosphate sodium from its major process impurities and degradation products was achieved on a hypersil bds c18 column (250 × 4.6 mm, 5 μm) with an a...

The antibiotic residues in milk are a well-known serious problem and pose several health hazards to consumers. We have described a simple, rapid, and inexpensive DLLME-HPLC/UV technique for the extraction of chloramphenicol and florfenicol residues in milk samples. Under the optimum conditions, linearity of the method was observed over the range 0.02-0.85 µg/L with correlation coefficients > 0....

In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of bosentan in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of bosentan at platinum electrode in acetonitrile solution containin...

In this study, a rapid, simple and sensitive ion mobility spectrometry (IMS) method with corona discharge as ionization source was described for the morphine determination in human urine. Morphine was extracted and purified from urine samples using solid phase extraction procedure with C18 column. It can offer the clean extracts which no extra peaks were observed in IMS. Under operating experim...

In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of bosentan in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of bosentan at platinum electrode in acetonitrile solution containin...

This study presents a robust and rigorous method based on intelligent models, namely radial basis function networks optimized by particle swarm optimization (PSO-RBF), multilayer perceptron neural networks (MLP-NNs), and adaptive neuro-fuzzy inference system optimized by particle swarm optimization methods (PSO-ANFIS), for predicting the equilibrium and kinetics of the adsorption of sulfur and ...

At the end of 2006 NVIDIA introduced a new generation of graphical processing units (GPUs) (the so called G80 architecture). These GPUs are more powerful than any of the GPUs released before; they offer up to 350 billion floating-point operations per second (GFLOP/s) in certain situations. With the introduction of this hardware NVIDIA released a new programming environment that makes it easier ...