Elevated intracellular Ca 2+ concentrations [Ca 2+ ] appear to be a rather universal trigger of massive membrane ca-pacitance increases, presumably refl ecting exocytosis of tiny vesicles (Borgonovo et al., 2002). The [Ca 2+ ] required to stimulate this response is very high. In this issue Yaradanakul et al. (see p. 29) report experiments with baby hamster kidney (BHK) cells expressing the Na +...