نتایج جستجو برای: regulatory t cells tregs

تعداد نتایج: 2028005  

2013
Tae Jung Jang

BACKGROUND We examined the distribution of CD8+ T cells and regulatory T cells (Tregs), measured the CD8+ T cell/Tregs ratio, investigated the relationship between Tregs and cyclooxygenase-2 (COX-2) expression during colorectal cancer (CRC) development. METHODS We performed immunohistochemical staining for CD8, forkhead box P3, E-cadherin, and COX-2 in 32 cases of invasive CRC, 10 cases of in...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Noritoshi Kobayashi Nobuyoshi Hiraoka Wataru Yamagami Hidenori Ojima Yae Kanai Tomoo Kosuge Atsushi Nakajima Setsuo Hirohashi

PURPOSE Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress the immune reaction. The aim of the present study was to investigate the clinicopathologic significance and roles of Tregs and CD8+ T cells during hepatocarcinogenesis. EXPERIMENTAL DESIGN We examined the infiltration of FOXP3+ Tregs and CD8+ T cells in the ...

Journal: :Science signaling 2017
Sadna Budhu David A Schaer Yongbiao Li Ricardo Toledo-Crow Katherine Panageas Xia Yang Hong Zhong Alan N Houghton Samuel C Silverstein Taha Merghoub Jedd D Wolchok

Regulatory T cells (Tregs) suppress antitumor immunity by inhibiting the killing of tumor cells by antigen-specific CD8+ T cells. To better understand the mechanisms involved, we used ex vivo three-dimensional collagen-fibrin gel cultures of dissociated B16 melanoma tumors. This system recapitulated the in vivo suppression of antimelanoma immunity, rendering the dissociated tumor cells resistan...

Journal: :Diabetes 2009
Amy L. Putnam Todd M. Brusko Michael R. Lee Weihong Liu Gregory L. Szot Taumoha Ghosh Mark A. Atkinson Jeffrey A. Bluestone

OBJECTIVE Regulatory T-cells (Tregs) have catalyzed the field of immune regulation. However, translating Treg-based therapies from animal models of autoimmunity to human clinical trials requires robust methods for the isolation and expansion of these cells-a need forming the basis for these studies. RESEARCH DESIGN AND METHODS Tregs from recent-onset type 1 diabetic patients and healthy contr...

2016
Hongna Yang Jinhua Sun Feng Wang Yan Li Jianzhong Bi Tingyu Qu

The immunoregulatory function of T regulatory cells (Tregs) is impaired in multiple sclerosis (MS). Recent studies have shown that umbilical cord-derived mesenchymal stem cells (UC-MSCs) exert regulatory effect on the functions of immune cells. Thus, we investigated whether UC-MSCs could improve the impaired function of Tregs from MS patients. Co-cultures of UC-MSCs with PBMCs of MS patients we...

Journal: :Folia histochemica et cytobiologica 2014
Maria Klatka Lucyna Kaszubowska Ewelina Grywalska Magdalena Wasiak Leszek Szewczyk Jerzy Foerster Marta Cyman Jacek Rolinski

Almost all cases of hyperthyroidism in children result from Graves' disease (GD). Recent studies have confirmed a significant role of T regulatory cells (Tregs) in the development of autoimmune diseases. However, the interactions between T cell responses and Treg proliferation in GD are still poorly understood. The aim of this study was to assess the proliferation of Treg cells (Tregs) and CD3+...

Journal: :Journal of Immunology 2023

Abstract Heatstroke is a life-threatening illness related to systematic inflammation-induced multiple organ dysfunction. The severity of inflammatory response may be the changes in immune regulation triggered by heat acclimation. However, mechanisms acclimation and its effect on are unclear. Here, we assessed differences immunocyte subsets spleen lymph nodes heat-acclimated mice. Higher frequen...

Journal: :Experimental dermatology 2015
Kazunari Sugita Sho Hanakawa Tetsuya Honda Gen Kondoh Yoshiki Miyachi Kenji Kabashima Takashi Nomura

Helios is a member of the Ikaros transcription factor family and has been reported to be a marker of thymus-derived regulatory T cells (Treg). Helios is an intracellular protein, however, and hence cannot be used as a marker to separate living Tregs. To solve this problem, we generated Helios reporter mice in which Helios+ cells selectively express Venus, a variant of green fluorescent protein....

2015
Bao-Xiang Zhang Jun-Cheng Lyu Hai-Bo Liu Dian-Qin Feng Dian-Cai Zhang Xing-Jie Bi Zhi-Wu Duan Gang Ding

PURPOSE Cutaneous lymphocyte-associated antigen (CLA)-expressing CD8⁺T cells have been known to play an important role in the pathogenesis of atopic dermatitis (AD). However, the mechanisms underlying the loss of self-tolerance remain unclear. Regulatory T cells (Tregs) play a key role in the development of homeostasis in the immune system. We, therefore, hypothesized that a reduced ability of ...

2016
Han Sol Choi Sang Yun Ha Hye-Mi Kim Soo Min Ahn Myung-Soo Kang Kyoung-Mee Kim Min Gew Choi Joon Ho Lee Tae Sung Sohn Jae Moon Bae Sung Kim Eun-Suk Kang

The prognostic effects of tumor infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs) and myeloid derived suppressing cells (MDSCs) are inconclusive in gastric cancers. We investigated the frequencies of TILs including CD8+ T cells, CD45+CD4+CD25± FOXP3+ Tregs, CD45+CD11b+ CD14+ HLA-DR- MDSCs in 28 gastric cancer tissues by using multicolor flow cytometry. In gastric cancer tis...

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