The real world exhibits concurrency at all levels of scale – from atomic, through human, to astronomic. This concurrency is endemic. Central points of control do not remain stable for long. Most of the novel paradigms identified in the GC7 description paper hint at something stronger – namely that central points of control actively work against the logic and efficiency of whatever it is that is...

the effect of motivational self-regulatory strategies on l2 learners’ achievement has scarcely been examined within the context of our country, iran. this study is concerned with examining the relationship between motivational self-regulatory strategies and their l2 reading and l2 writing achievement. it also explores the relationship of motivational self-regulatory strategies and use of langua...

The assessment of chemical mixtures is a complex topic for toxicologists, regulators, and the public. In this article the linkage between the science of toxicology and the needs of governmental regulatory agencies in the United States is explored through an overview of environmental regulations enacted over the past century and a brief history of modern toxicology. One of the goals of this over...

In 2011, the US Food and drug Administration (FDA) developed a strategic plan for regulatory science that focuses on developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products. In line with this, the Division of Applied Regulatory Science was created to move new science into the Center for Drug Evaluation and Research (CDER...

| Since the regulatory approval of ipilimumab in 2011, the field of cancer immunotherapy has been experiencing a renaissance. This success is based on progress in both preclinical and clinical science, including the development of new methods of investigation. Immuno-oncology has become a sub-specialty within oncology owing to its unique science and its potential for substantial and long-term c...

The functioning and development of living organisms – from bacteria to humans – are controlled by genetic regulatory networks composed of interactions between DNA, RNA, proteins, and small molecules. The size and complexity of these networks make an intuitive understanding of their dynamics difficult to attain. In order to predict the behavior of regulatory systems in a systematic way, we need ...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

background: regulatory t cells (tregs) have been involved in impaired immunity and may have a pivotal role in persistence of viral infections. objective: to develop a simple and reliable in-house three color flow cytometery of peripheral blood to understand the role of hcv infection in the increase of tregs. methods: the level of naturally occurring cd4+cd25+foxp3+ regulatory t cells (ntregs) i...

signal regulatory proteins (sirp) belong to immunoglobulin super family (igsf) and relate to integrin signaling cascades. it has been shown that sirpa is expressed in a variety of cells including myeloid cells and neurons. in the present study the expression of this igsf member in articular chondrocytes was investigated. methods: using a panel of anti-sirpalpha antibodies, immunohistochemistry,...