Cocaine and Amphetamine Regulated Transcript (CART) peptides are anorexigenic neuropeptides. The L34F mutation in human CART peptide precursor (proCART) has been linked to obesity (Yanik et al. Endocrinology 147: 39, 2006). Decrease in CART peptide levels in individuals carrying the L34F mutation was attributed to proCART subcellular missorting. We studied proCART features required to enter the...

In large multicast groups, the size of the group membership table maintained by RTP (Real Time Transport Protocol) participants may become unwieldy, particularly for embedded devices with limited memory and processing power. This document discusses mechanisms for sampling of this group membership table in order to reduce the memory requirements. Several mechanisms are proposed, and the performa...

BiP (immunoglobulin heavy-chain binding protein) is the endoplasmic reticulum (ER) orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most functions of this organelle through its interactions with a variety of substrates and regulatory proteins. Like all Hsp70 family members, the ability of BiP to bind and release unfolded proteins is tightly regulated by a cy...

Cancer cells communicate with the environment through delivery of surface proteins, release of soluble factors (growth factors and cytokines), and sophisticated nanovehicles (exosomes) for establishment of invasive tumor growth. This communication occurs in part through constitutive exocytosis, regulated exocytosis, or release of intraluminal vesicles, and is modulated by small Rab GTPases, the...

Dysregulation of regulated exocytosis is linked to an array of pathological conditions, including neurodegenerative disorders, asthma, and diabetes. Understanding the molecular mechanisms underpinning neuroexocytosis including the processes that allow neurosecretory vesicles to access and fuse with the plasma membrane and to recycle post-fusion, is therefore critical to the design of future the...

Published Ahead of Print 16 April 2012. 10.1128/MCB.06633-11. 2012, 32(13):2467. DOI: Mol. Cell. Biol. Sylvain Meloche, Matthias Gaestel and Alexey Kotlyarov Menon, Ruth Simon, Benjamin Turgeon, Stefan Britsch, Frank Brand, Stefanie Schumacher, Shashi Kant, Manoj B. Function and Dendrite Morphology 5 Signaling Complex Regulates Septin MAPK-Activated Protein Kinase − [MAPK6]) (Mitogen-Activated ...

In large multicast groups, the size of the group membership table maintained by RTP (Real Time Transport Protocol) participants may become unwieldy, particularly for embedded devices with limited memory and processing power. This document discusses mechanisms for sampling of this group membership table in order to reduce the memory requirements. Several mechanisms are proposed, and the performa...

responses of plants to salinity stress and development of salt tolerance are extremely complex and various mechanisms appear to be involved. we employed a proteomic approach to study the mechanism of plant responses to salinity in a sensitive cultivar of barley (527 line). three-week-old seedlings were treated with 300 mm nacl for 3 weeks. total proteins of fourth leaf were extracted and separa...

Restarting automata can be seen as analytical variants of classical automata as well as of regulated rewriting systems. We study a measure for the degree of nondeterminism of (context-free) languages in terms of deterministic restarting automata that are (strongly) lexicalized. This measure is based on the number of auxiliary symbols (categories) ∗Some of the results have been announced at CIAA...