نتایج جستجو برای: recruitment

تعداد نتایج: 62776  

2014
Leandro Galli Rosemary Knight Steven Robertson Elizabeth Hoile Olubukola Oladapo David Francis Caroline Free

BACKGROUND Recruitment is a major challenge for many trials; just over half reach their targets and almost a third resort to grant extensions. The economic and societal implications of this shortcoming are significant. Yet, we have a limited understanding of the processes that increase the probability that recruitment targets will be achieved. Accordingly, there is an urgent need to bring analy...

2013
Megan J. Metzler Deborah M. Saucier Gerlinde A. Metz

Aging is associated with deterioration of skilled manual movement. Specifically, aging corresponds with increased reaction time, greater movement duration, segmentation of movement, increased movement variability, and reduced ability to adapt to external forces and inhibit previously learned sequences. Moreover, it is thought that decreased lateralization of neural function in older adults may ...

2013
Tyler A. Lesh Andrew J. Westphal Tara A. Niendam Jong H. Yoon Michael J. Minzenberg J. Daniel Ragland Marjorie Solomon Cameron S. Carter

Cognitive control deficits have been consistently documented in patients with schizophrenia. Recent work in cognitive neuroscience has hypothesized a distinction between two theoretically separable modes of cognitive control-reactive and proactive. However, it remains unclear the extent to which these processes are uniquely associated with dysfunctional neural recruitment in individuals with sc...

Journal: :Social cognitive and affective neuroscience 2016
Brittany S Cassidy Eunice J Lee Anne C Krendl

Decreased executive ability elicits racial bias. We clarified the neural correlates of how executive ability contributes to race perception by comparing young adults (YA) to a population with highly variable executive ability: older adults (OA). After replicating work showing higher race bias in OA vs YA and a negative association between bias and executive ability, a subsample of White YA and ...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2015
Mark B Badrov Charlotte W Usselman J Kevin Shoemaker

This study tested the hypothesis that neural coding patterns exist within the autonomic nervous system. We investigated sympathetic axonal recruitment strategies in humans during chemoreflex- and baroreflex-mediated sympathoexcitation using a novel action potential (AP) analysis technique. Muscle sympathetic nerve activity (microneurography) was collected in 11 young individuals (6 females) dur...

Journal: :The EMBO journal 2012
Ian C Berke Yorgo Modis

Melanoma differentiation-associated gene-5 (MDA5) detects viral double-stranded RNA in the cytoplasm. RNA binding induces MDA5 to activate the signalling adaptor MAVS through interactions between the caspase recruitment domains (CARDs) of the two proteins. The molecular mechanism of MDA5 signalling is not well understood. Here, we show that MDA5 cooperatively binds short RNA ligands as a dimer ...

2014
Mahvash Shere Xiu Yan Zhao Gideon Koren

BACKGROUND Recruitment of women in the periconceptional period to clinical studies using traditional advertising through medical establishments is difficult and slow. Given the widespread use of the internet as a source for medical information and research, we analyze the impact of social media in the second phase of an ongoing randomized, open-label clinical trial among pregnant women. This st...

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