The NH(2) terminus (residues 1-59) of streptokinase (SK) is a molecular switch that permits fibrin-independent plasminogen activation. Targeted mutations were made in recombinant (r) SK1-59 to identify structural interactions required for this process. Mutagenesis established the functional roles of Phe-37and Glu-39, which were projected to interact with microplasmin in the activator complex. M...

8. Stump DC, Califf RM, Topol EJ, Sigmon K, Thornton D, Masek R, Anderson L, Collen D, and the TAMI Study Group. Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator: correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction. Circulation.

RCVS: Reversible Cerebral Vasoconstriction Syndrome; rtPA: recombinant tissue Plasminogen Activator; GCS: Glasgow Coma Scale; CT: Computed Tomography; ICH: Intracerebral Hemorrhage; MRI: Magnetic Resonance Imaging; MRR: MR Renography; ACA: Anterior Cerebral Artery; MIS: Minimally Invasive Surgery; TCD: Transcranial Doppler; ICU: Intensive Care Unit; MISTIE: Minimally Invasive Surgery plus rt-PA...

Abbreviations: ASPECTS: Alberta Stroke Program Early CT Score; CT: Computed Tomography; EIC: Early Ischemic Changes; FKA: First Known Abnormal; IQR: Interquartile Range; IV: Intravenous; LKN: Last Known Normal; mRS: modified Rankin Scale; MRI: Magnetic Resonance Imaging; rtPA: recombinant Tissue plasminogen Activator; SD: Standard Deviation; SICH: Symptomatic Intracerebral Haemorrhage; SITS-MOS...

The reaction of recombinant tissue-type plasminogen activator with the inverse substrate 4-amidino-2-nitrophenyl 4'-anisate results in the rapid release of the chromogen 4-amidino-2-nitrophenol and the accumulation of the relatively stable 4-anisoyl-enzyme. Spectrophotometric monitoring of the reaction enables the operational molarity of the enzyme to be determined.

A case of massive pulmonary embolism complicated by acute cor pulmonale and shock is presented. The IV administration of recombinant tissue-type plasminogen activator (rt-PA) was associated with prompt reversal of clinical, ECG, and nuclear radiographic findings. The role of thrombolytic therapy with rt-PA for massive pulmonary embolism associated with hemodynamic decompensation deserves furthe...

rt-PA Recombinant tissue plasminogen activator SK Streptokinase UK Urokinase Pro-UK Prourokinase TNK Tenecteplase MCA Middle cerebral artery IU International units ICH Intracerebral hemorrhage PET Positron emission tomography IV Intravenous IA Intra-arterial d: Days Chapter 2 The March of Thrombolytic Therapy for Acute Ischemic Stroke to Clinical Trials: Pre-clinical Thrombolysis and Adjuncts t...

ALI = acute limb ischemia, APSAC = antistreplase, MTD = mechanical thromboembolectomy device, PAT = percutaneous aspiration thromboembolectomy, pro-UK = prourokinase, RPA = reteplase, r-UK = recombinant urokinase, SK = streptokinase, STILE = Surgery versus Thrombolysis for Ischemia of the Lower Extremity [study], tPA = tissue plasminogen activator, TOPAS = Thrombolysis or Peripheral Arterial Su...