background: among diverse protein purification systems, affinity chromatography is the most attractive one in the purification process of coagulation factors. coagulation factor vii is a plasma serine protease that has a significant role in natural human hemostasis and its recombinant form such as aryoseventm, has been applied in clinical treatment of bleeding disorders. immunoaffinity chromato...

Raw starch degrading enzyme specially glucoamylase with binding domain (SBD) has great values in the processing industry because it digests particles below gelatinization temperature by releasing glucose from non-reducing ends sequentially. The purpose of study was to measure secretion levels recombinant Pichia pastoris, using α-mating factor signal peptide (α-MF) and native Aspergillus flavus ...

To identifying of the high yielding wheat lines with optimal characteristics and to determine the traits which could be used as the selection index for increasing of grain yield, 40 recombinant inbred lines derived from a cross between Norstar and Zagros cultivars were evaluated in a randomized complete block design with three replications. The measured characters consisted of peduncle weight, ...

Bakground: Granulocyte colony-stimulating factor (G-CSF) is a cytokine that stimulates hematopoiesis and induces proliferation and differentiation of granulocyte progenitor cells as well as production of bone marrow neutrophilic granulocyte colonies.  Nowadays, human recombinant G-CSF(hr G-CSF)is used for the treatment of chemotherapy- and radiotherapy-induced neutropenia, and also in patients ...

objective(s): helicobacter pylori, a human specific gastric pathogen is a causative agent of chronic active gastritis. the vacuolating cytotoxin (vaca) is an effective virulence factor involved in gastric injury. the aim of this study was to construct a recombinant protein containing antigenic region of vaca gene and determine its antigenicity.   materials and methods: the antigenic region of v...

Essentials Factor VIII inhibitors are the most serious complication in patients with hemophilia A. Aggregates in biopharmaceutical products are an immunogenic risk factor. Aggregates were identified in recombinant full-length factor VIII products. Aggregates in recombinant factor VIII products are identified by analytical ultracentrifugation. SUMMARY Background The development of inhibitory a...