The β2-adrenergic receptor, located in the prostate region, binds noradrenaline and can influence growth of tumors. removal Adrb2, gene for this halt tumor thus serve as an alternative to chemotherapy cancer treatment. Inhibition receptor may have similar effects. Comparison β2- (PDB ID: 5X7D) β1-adrenergic 2Y04) structures showed a conserved binding region on Chain A offset by approximately ei...

Background: Previous investigations have revealed, cimetidine, a histamine H2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. In this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine H2-receptor antagonists, was investigated. Materials and Methods : Balb/c m...

conclusions ip injection of cb1 receptor antagonist might have an anxiogenic profile in rat, whereas calcium channel blocker attenuated the anxiogenic effect of am251. our results suggest that there is an interaction between functions of l-type ca2+ channels and cannabinoid system in anxiety. background the elevated plus-maze (epm) has been broadly used to investigate anxiolytic and anxiogenic ...

objective: the objective of this study was to investigate inhibition and anti-cancer effects of linoleic acid on the mcf-7 and mda-mb-231 human breast cancer cells. materials and methods: cell lines human breast cancer mcf-7 (gdc055) and mda-mb-231 (htb-26) cell lines were obtained from atcc. mcf-7 estrogen receptor positive human breast cancer cell line and  the estrogen receptor negative huma...

In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Intraperitoneal (i.p.) injection of acute and repeated morphine at increasing doses significantly enhanced glutamate release. Only a minor tolerance developed to this dosage of morphine. AP-S (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a N...

background hymenodictyon excelsum is a medicinal plant traditionally used for tumor treatment as it contains phytochemicals of anthraquinone and coumarin class. objectives the aim of the present study was to unfold the therapeutic value of selected phytocompounds of hymenodictyon excelsum in prostate cancer. materials and methods eight phytochemicals were selected based on the literature search...

introduction: the plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is to assess the effects of hippocampal 5-ht4 receptor on memory acquisition deficit induced by harmaline.  methods: harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs...

Background: Euphorbia plants are traditionally used in folk medicine for infections, inflammation, and cancer. Objectives: To investigate the effects of the butanolic extracts of Euphorbia micorociadia and Euphorbia osyridea on specific transcription factors and cytokines expression of T cell subsets. Methods: Activated mouse splenocytes were cultured in the presence of non-cytotoxic concentrat...

Introduction: Oxytocin is a active neuropeptide of central nervous system. In this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (LC) nucleus were investigated. Methods: Adult male Wistar rats were used. Animals divided into different groups receiving saline, oxy...