Epidermolysis bullosa (EB) comprises a collection of clinically diverse inherited blistering diseases that affect the skin and, in some subtypes, mucous membranes and other organs. Currently classified into four main subtypes (EB simplex, junctional EB, dystrophic EB, and Kindler syndrome, mainly based on the level of skin cleavage), the spectrum of EB extends to more than 30 clinical subtypes ...

Simple, sensitive and specific predictors of mortality in the critically ill remain elusive goals, and brain natriuretic peptide and venous lactate are the subjects of recent studies. The role of vasopressin in sepsis continues to be the focus of much research interest. Dose ranging studies, potential adverse effects, and selective V1 agonists are discussed below in recent trials. Finally the u...

We investigate a widely popular least-recently-used (LRU) cache replacement algorithmwith semiMarkov modulated requests. Semi-Markov processes provide the flexibility for modeling strong statistical correlation, including the widely reported long-range dependence in theWorldWideWeb page request patterns. When the frequency of requesting a page n is equal to the generalized Zipf’s law c/n , > 1,...

In this chapter we discuss some open problems related to fuzzy implications, which have either been completely solved or those for which partial answers are known. In fact, this chapter also contains the answer for one of the open problems, which is hitherto unpublished. The recently solved problems are so chosen to reflect the importance of the problem or the significance of the solution. Fina...