Owing to their fast diffusion, reactive oxygen species (ROS) are important tissue signalling components. High levels of ROS are generally considered as deleterious to cells. In vivo experiments in the Drosophila hematopoietic organ now challenge this view by showing that high ROS levels are intrinsically required to prime myeloid-like progenitors to differentiate.

We consider the non-reactive elastic Boltzmann equation for multicomponent gaseous mixtures. We deduce, under the standard diffusive scaling, that well prepared initial conditions lead to solutions satisfying the Maxwell-Stefan diffusion equations in the vanishing Mach and Knudsen numbers limit.

BACKGROUND The calculation of diffusion-controlled ligand binding rates is important for understanding enzyme mechanisms as well as designing enzyme inhibitors. METHODS We demonstrate the accuracy and effectiveness of a Lagrangian particle-based method, smoothed particle hydrodynamics (SPH), to study diffusion in biomolecular systems by numerically solving the time-dependent Smoluchowski equa...