Background. Data on iron and vitamin A deficiency are scarce in school-aged children living with HIV (HIV+) compared without (HIV–). Both deficiencies can contribute to anaemia.
 Objective. To assess anaemia, status a sample of HIV+ HIV– South Africa.
 Methods. In this comparative cross-sectional study, biomarkers for anaemia (haemoglobin), (plasma ferritin (PF), soluble transferrin r...

Notch proteins comprise a family of transmembrane receptors. Ligand activation of Notch releases the intracellular domain of the receptor that translocates to the nucleus and regulates transcription through the DNA-binding protein RBP-Jkappa. Previously, it has been shown that the Notch4 intracellular region (N4IC) can inhibit endothelial sprouting and angiogenesis. Here, N4IC deletion mutants ...

Signaling through Notch receptors and their transcriptional effector RBP-J is essential for lymphocyte development and function, whereas its role in other immune cell types is unclear. We tested the function of the canonical Notch-RBP-J pathway in dendritic cell (DC) development and maintenance in vivo. Genetic inactivation of RBP-J in the bone marrow did not preclude DC lineage commitment but ...

Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is essential for efficient conversion of primary human B lymphocytes to lymphoblastoid cell lines (LCLs) and for continued LCL growth. We used a transcomplementation assay in the context of LCLs transformed by an EBV with a conditional EBNA3C to identify the EBNA3C amino acids (aa) necessary for maintaining LCL growth. Surprisingly, we found ...

The aim of the investigation is to develop a control method of a rotary blood pump (RBP) to solve the following problems: estimation of the pump flow rate, achievement and maintaining of the desired flow level through the continuous adjustment of pump speed and prevention of adverse effects on the cardiovascular system. Results. Functional chart of RBP control consists of several units: a unit ...

PURPOSE To study normative ranges, learning effect (LE), test-retest variability (TRV), and influence of blur and cataract in normal subjects by using rarebit perimetry (RBP). METHODS Seventy-five normal subjects underwent visual field (VF) testing with standard automated perimetry (SAP) and RBP. LE and TRV for RBP were assessed in repeated examinations conducted on four different days. LE wa...

12-O-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter of the phorbol ester type and protein kinase C (PKC) activator, consists of two characteristic structural elements: the phorbol body and the retinoyl ester chain. Therefore, possible binding of the incomplete tumor promoter RPA to the human transport protein retinol-binding-protein (RBP) has been examined by molecular modeling ...

The retinol-binding protein (RBP) and thyroxine-binding prealbumin were isolated from rat serum. Under physiological conditions RBP and prealbumin form a protein complex. Rat RBP exhibited characteristics very similar to those previously encountered for the human and monkey counterparts, including the association constant to prealbumin (8 x lo6 M-l). Thyroxine-binding prealbumin in rat is in co...

Laying chickens normally produce a riboflavin-binding protein (RBP) essential for the transfer of vitamin B2 to the egg. A mutant line of chickens (rdrd) is incapable of synthesizing functional RBP. The rdrd laying hens contain a component in the liver and the magnum of the oviduct which cross-reacts with rabbit antiserum specific for RBP. No crossreacting material (CRM) was observed in eggs or...