BACKGROUND Experimental models are necessary to elucidate diabetes pathophysiological mechanisms not yet understood in humans. OBJECTIVE To evaluate the repercussions of the mild diabetes, considering two methodologies, on the pregnancy of Wistar rats and on the development of their offspring. METHODS In the 1st induction, female offspring were distributed into two experimental groups: Grou...

Objective(s): Oleate can be produced through de novo synthesis, which contributes to biological processes and signaling pathways. However, the role of this non-essential fatty acid in hepatic development remains unclear. The current study aimed to evaluate the influence of early oleate deficiency induced by the inhibitor of de novo oleate synthesis MF-438 on fetal rat ...

trauma during pregnancy is remarkably common, motor vehicle crashes are cause of hospitalized trauma during pregnancy. trauma occurs in 5% of pregnancies that appropriate high proportion of maternal and fetal mortality. motor vehicle crashes, falls, assaults, including domestic violence, are all important mechanisms of injury. motor vehicle accidents account for more than 50% of all traumas dur...

vitex agnus castus (chasteberry) is a popular treatment for the management of female reproductive disorders including corpus luteum insufficiency, premenstrual syndrome (pms), menopausal symptoms, and insufficient milk production. according to developing situation of complementary medicine, and frequent use of this herb, it is important to examine its effects during pregnancy. in this research ...

in mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. changes in the intrauter...